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Merck
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重要文件

P8014

Sigma-Aldrich

4α-佛波醇 12,13-二癸酸酯

solid

同義詞:

4α-佛波醇 12-13-二癸酸酯, 4αPDD

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About This Item

經驗公式(希爾表示法):
C40H64O8
CAS號碼:
分子量::
672.93
Beilstein:
2514324
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.77
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形狀

solid

品質等級

顏色

white

溶解度

DMSO: soluble
ethanol: soluble
methanol: soluble

儲存溫度

−20°C

SMILES 字串

CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC

InChI

1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

InChI 密鑰

DGOSGFYDFDYMCW-OEFRVDPMSA-N

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應用

4α-佛波醇12,13-二癸酸酯作为瞬时受体电位香草醛4(TRPV4)激动剂的应用实例:
  • 研究其对Madin-Darby犬肾(MDCK)细胞的影响[1]
  • 研究其对小鼠输卵管细胞Ca2+内流的影响[2]
  • 研究其对小鼠足趾肿胀的影响[3]

生化/生理作用

4α-佛波醇12,13-二癸酸酯是一种瞬时受体电位香草醛4(TRPV4)激动剂,可促进胞外钙离子内流进入细胞。[4]

注意

光敏性

重構

不能使用水性介质制备储液;溶解于与水混溶的有机溶剂中,然后在水性介质中稀释至工作浓度。

訊號詞

Danger

危險分類

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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T A Rose-Hellekant et al.
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Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin.
W M Baird et al.
Cancer research, 31(8), 1074-1079 (1971-08-01)
M C LaPointe et al.
Molecular endocrinology (Baltimore, Md.), 7(10), 1284-1296 (1993-10-01)
During left ventricular hypertrophy, brain natriuretic peptide (BNP) and atrial natriuretic factor (ANF) mRNA levels increase, possibly due to stretch-induced activation of protein kinase C. Phorbol ester treatment of primary cultures of neonatal rat ventricular cardiocytes represents an in vitro
Noriyuki Hatano et al.
Life sciences, 85(23-26), 808-814 (2009-11-03)
Vanilloid type transient receptor potential channel (TRPV) could be a potential environmental sensor to multiple stimuli in many types of cells. In this study, we provide the first evidence of functional vanilloid type 4 transient receptor potential channel (TRPV4) in

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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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