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重要文件

S3065

Sigma-Aldrich

SC 19220

≥98% (HPLC), solid

同義詞:

2-乙酰肼 10 (11H)-羧酸, 8-氯代二苯 [b,f] [1,4] 恶嗪-10 (11H)-羧酸

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About This Item

經驗公式(希爾表示法):
C16H14N3O3Cl
CAS號碼:
分子量::
331.75
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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化驗

≥98% (HPLC)

形狀

solid

顏色

white

mp

190-191 °C (lit.)

溶解度

DMSO: soluble 10 mg/mL
H2O: insoluble

SMILES 字串

CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13

InChI

1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)

InChI 密鑰

KNURFLJTOUGOOQ-UHFFFAOYSA-N

基因資訊

human ... PTGER1(5731)
rat ... Ptger1(25637)

應用

采用 SC 19220 研究前列腺素 E 2 在大鼠皮质培养物中氧糖剥夺诱导的神经毒性和预处理诱导的神经保护中的作用。[1]

生化/生理作用

EP 1 前列腺素受体拮抗剂
SC 19220 是前列腺素 E 受体的竞争性拮抗剂。它与 PGE 2 竞争调节膀胱尿道运动,并增加大鼠膀胱容量。[2]它能抑制平滑肌对前列腺素 E 2 和 F 2α 的收缩反应[3]SC 19220 还可抑制维生素 D3、甲状旁腺激素、IL-11 和 IL-6 诱导的破骨细胞的形成。[4]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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S Santangelo et al.
The Journal of trauma, 48(5), 826-830 (2000-05-24)
Although prostaglandin E2 (PGE2) has been shown to be immunosuppressive, its role in the development of specific bone marrow myeloid lineages after thermal injury and sepsis has yet to be elucidated. The purpose of this study was to demonstrate that
K Oka et al.
The American journal of physiology, 275(6 Pt 2), R1762-R1765 (1998-12-09)
We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central
L Walch et al.
British journal of pharmacology, 134(8), 1671-1678 (2001-12-12)
1. To characterize the prostanoid receptors (TP, FP, EP(1) and/or EP(3)) involved in the vasoconstriction of human pulmonary veins, isolated venous preparations were challenged with different prostanoid-receptor agonists in the absence or presence of selective antagonists. 2. The stable thromboxane
J B Farmer et al.
British journal of pharmacology, 52(4), 559-565 (1974-12-01)
1 The effects of the prostaglandin synthetase inhibitor, indomethacin and the prostaglandin antagonist SC-19220 (1-acetyl-2-[8-chloro-10,11-dihydrodibenz (b,f) (1,4)oxazepine-10-carbonyl] hydrazine), were examined on the tone of the guinea-pig isolated tracheal preparation and on the responses of the preparation to prostaglandin F(2alpha), arachidonic
K Fushimi et al.
Osteoarthritis and cartilage, 12(11), 895-903 (2004-10-27)
Calpains are known as Ca(2+)-dependent intracellular neutral cysteine proteases. However, m-calpain is detected in synovial fluid of arthritic joints and is shown to possess the proteoglycanase activity in vitro. The mechanism of m-calpain release into the extracellular spaces during arthritis

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