跳轉至內容
Merck
全部照片(1)

重要文件

檢視所有文件

S153

Sigma-Aldrich

SQ 22,536

≥97% (HPLC), powder

同義詞:

9-THF-Ade, 9-（四氢-2-呋喃基）-9H-嘌呤-6-胺

登入查看組織和合約定價
全部照片(1)

About This Item

經驗公式（希爾表示法）:
C9H11N5O
CAS號碼:
17318-31-9
分子量：:
205.22
MDL號碼:
MFCD00210216
分類程式碼代碼:
41106305
PubChem物質ID:
24278057
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥97% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

DMSO: >10 mg/mL
H2O: insoluble

SMILES 字串

Nc1ncnc2n(cnc12)C3CCCO3

InChI

1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)

InChI 密鑰

UKHMZCMKHPHFOT-UHFFFAOYSA-N

基因資訊

human ... ADCY1(107) , ADCY2(108) , ADCY3(109) , ADCY4(196883) , ADCY5(111) , ADCY6(112) , ADCY7(113) , ADCY8(114) , ADCY9(115)
rat ... Adora1(29290) , Adora2a(25369)

尋找類似的產品？ 前往 產品比較指南

應用

SQ 22,536已被用于研究腺苷酸环化酶在PC12细胞分化[1] 和乳腺癌细胞中的间隙连接细胞间通讯中的作用。[2]

生化／生理作用

SQ 22,536不仅是血小板中基础腺苷酸环化酶，也是前列腺素E1激活的腺苷酸环化酶活性的有效抑制剂。1 当对大鼠进行肌肉注射时，它可以对侧和同侧逆转痛觉过敏。2
SQ 22,536是一种细胞可渗透的腺苷酸环化酶抑制剂。在去污剂剂分散的大鼠脑制剂中，IC50 = 20 μM。

特點和優勢

该化合物是受体分类及信号转导手册上腺苷酸环化酶页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000432345
0000432345
0000282379
0000282379
0000155719

未看到正確版本？

如果您需要一個特定的版本，您可以透過批號來尋找特定憑證。

搜尋 COA

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

R J Haslam et al.
The Biochemical journal, 176(1), 83-95 (1978-10-15)
Whereas adenosine itself exerted independent stimulatory and inhibitory effects on the adenylate cyclase activity of a platelet particulate fraction at low and high concentrations respectively, 2-substituted and N6-monosubstituted adenosines had stimulatory but greatly decreased inhibitory effects. Deoxyadenosines, on the other
Kausar M Ansari et al.
Molecular cancer research : MCR, 6(6), 1003-1016 (2008-06-24)
Although prostaglandin E2 (PGE2) has been shown by pharmacologic and genetic studies to be important in skin cancer, the molecular mechanism(s) by which it contributes to tumor growth is not well understood. In this study, we investigated the mechanisms by
C Lippe et al.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 99(1-2), 209-211 (1991-01-01)
1. The effects of both adenyl cyclase inhibitors (MDL12330A and SQ22536) have been studied on the ionic transport induced by vasopressin and isoprenaline across the frog skin. 2. MDL12330A inhibits the vasopressin action on the short-circuit current (SCC), confirming that
Hari Hendarto et al.
Metabolism: clinical and experimental, 61(10), 1422-1434 (2012-05-05)
Accumulating evidence has implicated that GLP-1 may have a beneficial effect on cardiovascular and renal diseases but the mechanism is not fully understood. Here we show that GLP-1 analog, liraglutide, inhibits oxidative stress and albuminuria in streptozotocin (STZ)-induced type 1
Marie K Hoeger-Bement et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 23(13), 5437-5445 (2003-07-05)
Spinal activation of the cAMP pathway produces mechanical hyperalgesia, sensitizes nociceptive spinal neurons, and phosphorylates the transcription factor cAMP-responsive element binding protein (CREB), which initiates gene transcription. This study examined the role of the cAMP pathway in a model of
查看所有相關論文

文章

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Questions

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務