RAB1050

人半乳凝素-8 ELISA试剂盒

for cell culture supernatants, plasma, and serum samples

• 分類程式碼代碼: 41116158
• NACRES: NA.32

屬性

• 物種活性: human
• 包裝: kit of 96 wells (12 strips x 8 wells)
• 技術: ELISA: suitable
• 輸入: sample type plasma; sample type serum sample(s); sample type cell culture supernatant(s)
• assay range: inter-assay cv: <12%; intra-assay cv: <10%; sensitivity: 0.16 ng/ml
• 檢測方法: colorimetric
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... LGALS8(3964)

描述

一般說明

This ELISA antibody pair detects Human Galectin-8 (LGALS8)

應用

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

生化／生理作用

Galectin-8 (Gal-8) is a member of “tandem-repeat” galectin family, possesses two carbohydrate binding domains linked by a short peptide. The short peptide accounts for Gal-8 cell adhesion and downstream signalling.[1] Tumor cells, as well as normal tissues, express Gal-8.[2] The expression level of Gal-8 is higher in multiple myeloma conditions and enhances adhesion to vascular endothelium.[1] Galectin-8 binds to integrin selectively and inhibits cell adhesion and promotes apoptosis.[3] Gal-8 interacts with integrin alpha and regulates neutrophil adhesion to endothelial cells and migration.[2] Gal-8 ligand binds to cluster of differentiation 44 (CD44) and causes an inflammatory response in rheumatoid arthritis.[4] Overexpression of Gal-8 plays a key role in metastasis of prostate cancer and cell survival by causing rearrangement of the cytoskeleton and E-cadherin expression.[5]

其他說明

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

安全資訊

• 象形圖: GHS05
• 訊號詞: Warning
• 危險聲明: H290
• 防範說明: P234 - P390
• 危險分類: Met. Corr. 1
• 儲存類別代碼: 8A - Combustible corrosive hazardous materials
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable