推薦產品
物種活性
human
包裝
kit of 96 wells (12 strips x 8 wells)
技術
ELISA: suitable
輸入
sample type serum sample(s)
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.12 ng/ml
檢測方法
colorimetric
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... ADAMTS4(9507)
一般說明
Human a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) enzyme-linked immunosorbent assay (ELISA) kit is an in vitro ELISA kit for the quantitative measurement of a human ADAMTS4 in biological samples, such as serum, plasma, cell culture supernatants, urine, and/or cell and tissue lysates. ADAMTS4 is a multidomain metalloproteinase that can inhibit the activity of aggrecan. It belongs to the ADAMTS family. ADAMTS4 is made up of a pro-domain, a catalytic metalloproteinase domain, a disintegrin-like (Dis) domain, a thrombospondin type I (TS) domain. It also contains a cysteine-rich (CysR) domain and a spacer (Sp) domain. ADAMTS4 gene is located on the human chromosome at 1q23.3.
This ELISA antibody pair detects Human ADAMTS-4
應用
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
其他說明
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
訊號詞
Warning
危險聲明
防範說明
危險分類
Met. Corr. 1
儲存類別代碼
8A - Combustible corrosive hazardous materials
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study
Wang X Z, et al.
Cancer Medicine, 8(18), 7869-7880 (2019)
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
Fushimi K, et al.
The Journal of Biological Chemistry, 283(11), 6706-6716 (2008)
Michael Stock et al.
Arthritis & rheumatology (Hoboken, N.J.), 69(6), 1233-1245 (2017-01-14)
Cartilage damage and subchondral bone changes are closely connected in osteoarthritis. Nevertheless, how these processes are interlinked is, to date, incompletely understood. This study was undertaken to investigate the mechanistic role of a cartilage-derived protein, upper zone of growth plate
Jianjun Chen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(4), 1693-1703 (2018-04-26)
ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions. The aim of the present study was to investigate: 1) the mutation, copy-number alterations, and
Guping Mao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 44(1), 38-52 (2017-12-15)
Aggrecanase-1 (ADAMTS-4) and aggrecanase-2 (ADAMTS-5) are secreted enzymes belonging to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family that play significant roles in the progression of osteoarthritis (OA). Here, we aimed to determine whether the expression of ADAMTS-4/5
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