PZ0176
SC-26196
≥98% (HPLC)
同義詞:
SC-26196, a,a-diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile; 2,2-diphenyl-5-(4-[[(1 E)-pyridin-3-yl-methylidene]amino]piperazin-1-yl)pentanenitrile
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About This Item
經驗公式（希爾表示法）:
C27H29N5
CAS號碼:
分子量：:
423.55
MDL號碼:
分類程式碼代碼:
41121801
PubChem物質ID:
NACRES:
NA.77
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化驗
≥98% (HPLC)
形狀
powder
顏色
white to tan
溶解度
DMSO: ≥10 mg/mL
儲存溫度
2-8°C
SMILES 字串
N#CC(CCCN1CCN(CC1)\N=C\c2cccnc2)(c3ccccc3)c4ccccc4
InChI
1S/C27H29N5/c28-23-27(25-10-3-1-4-11-25,26-12-5-2-6-13-26)14-8-16-31-17-19-32(20-18-31)30-22-24-9-7-15-29-21-24/h1-7,9-13,15,21-22H,8,14,16-20H2/b30-22+
InChI 密鑰
QFYKXKMYVYOUNJ-JBASAIQMSA-N
應用
SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase:
- in mouse inner medullary collecting duct (IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) component[1]
- in hepatic HepG2 cells[2]
- in glioblastoma cell lines to test its effect post-radiation treatments[3]
生化／生理作用
Delta6-desaturase inhibitor
SC-26196 is a Delta6 fatty acid desaturase (Delta6D) inhibitor. It specifically inhibited Delta6D activity with an IC(50) value of 100 nM. The rate-limiting step in arachidonic acid synthesis is the desaturation of dietary linoleic acid by Delta6D. SC-26196 completely prevented this conversion of linoleic acid to arachidonic acid.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jie Wang et al.
Cancer management and research, 10, 6779-6790 (2018-12-26)
It has been reported that cell inflammation pathways contribute to the development of prostaglandin E2 (PGE2)-inhibitor of DNA-binding protein-1 (ID1)-dependent radio-resistance in glioblastoma. Here, we proposed that inhibiting delta-6-desaturase (D6D) could block arachidonic acid synthesis and PGE2 production, thereby reversing
Aiguo Wu et al.
Biochimica et biophysica acta, 1852(5), 951-961 (2015-01-01)
Dietary deficiency of docosahexaenoic acid (C22:6 n-3; DHA) is linked to the neuropathology of several cognitive disorders, including anxiety. DHA, which is essential for brain development and protection, is primarily obtained through the diet or synthesized from dietary precursors, however
Wondong Kim et al.
Cell metabolism, 29(4), 856-870 (2019-01-29)
The reactions catalyzed by the delta-5 and delta-6 desaturases (D5D/D6D), key enzymes responsible for highly unsaturated fatty acid (HUFA) synthesis, regenerate NAD+ from NADH. Here, we show that D5D/D6D provide a mechanism for glycolytic NAD+ recycling that permits ongoing glycolysis
Omega-3 and omega-6 fatty acid differentially impact cardiolipin remodeling in activated macrophage.
Wan-Hsin Chang et al.
Lipids in health and disease, 17(1), 201-201 (2018-08-30)
The macrophage plays an important role in innate immunity to induce immune responses. Lipid replacement therapy has been shown to change the lipid compositions of mitochondria and potentially becomes an alternative to reduce the inflammatory response. We examined the effects
Jiajun Du et al.
Nature communications, 11(1), 4830-4830 (2020-09-26)
Non-invasively probing metabolites within single live cells is highly desired but challenging. Here we utilize Raman spectro-microscopy for spatial mapping of metabolites within single cells, with the specific goal of identifying druggable metabolic susceptibilities from a series of patient-derived melanoma
文章
Discover Bioactive Small Molecules for Lipid Signaling Research
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