推薦產品
形狀
solid
溶解度
H2O: ≤24 mg/mL
SMILES 字串
Cl.O=C(OCCN1CCOCC1)C2(CCCCC2)c3ccccc3
InChI
1S/C19H27NO3.ClH/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17;/h1,3-4,7-8H,2,5-6,9-16H2;1H
InChI 密鑰
QUJWFJNHTBKCLU-UHFFFAOYSA-N
基因資訊
human ... OPRS1(10280)
rat ... Oprs1(29336) , Slc6a3(24898)
生化／生理作用
PRE-084一种有效且高度选择性的σ1 阿片受体激动剂。它在栓塞性中风可提供神经保护。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
Stefanie Vogler et al.
Neuroscience letters, 610, 13-18 (2015-10-27)
Water accumulation in retinal glial (Müller) and neuronal cells resulting in cellular swelling contributes to the development of retinal edema and neurodegeneration. Sigma (σ) receptor activation is known to have neuroprotective effects in the retina. Here, we show that the
T Maurice et al.
British journal of pharmacology, 127(2), 335-342 (1999-06-29)
1. Sigma (sigma) receptor ligands were previously reported to alleviate learning and memory impairments on several pharmacological and pathological rodent models of amnesia. Such effect was demonstrated as involving the sigma1 subtype of sigma receptor. 2. In this study, we
Judit Hodrea et al.
International journal of molecular sciences, 24(14) (2023-07-29)
Primary open-angle glaucoma remains a global issue, lacking a definitive treatment. Increased intraocular pressure (IOP) is considered the primary risk factor of the disease and it can be caused by fibrotic-like changes in the trabecular meshwork (TM) such as increased
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
Allahtavakoli M and Jarrott B
Brain Research Bulletin, 85(3-4), 219-224 (2011)
Yuriko Kimura et al.
PloS one, 8(10), e75760-e75760 (2013-10-12)
Sigma-1 receptor (Sig-1R) is an integral membrane protein predominantly expressed in the endoplasmic reticulum. Sig-1R demonstrates a high affinity to various synthetic compounds including well-known psychotherapeutic drugs in the central nervous system (CNS). For that, it is considered as an
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