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Merck
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文件

A114

Sigma-Aldrich

(+)-N-Allylnormetazocine hydrochloride

≥98% (HPLC)

同義詞:

(+)-NANM hydrochloride, SKF-10047, SKF10047, [2S-(2α, 6α,11R*)]-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride

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About This Item

經驗公式（希爾表示法）:
C17H23NO · HCl
CAS號碼:
133005-41-1
分子量：:
293.83
MDL號碼:
MFCD00078552
分類程式碼代碼:
12352200
PubChem物質ID:
24278250
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

光學活性

[α]21/D +90.6°, c = 1 in ethanol(lit.)

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

儲存條件

desiccated

顏色

white

溶解度

H2O: >10 mg/mL

儲存溫度

room temp

SMILES 字串

Cl[H].C[C@@H]1[C@@H]2Cc3ccc(O)cc3[C@@]1(C)CCN2CC=C

InChI

1S/C17H23NO.ClH/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17;/h4-6,11-12,16,19H,1,7-10H2,2-3H3;1H/t12-,16+,17+;/m1./s1

InChI 密鑰

ZTGMHFIGNYXMJV-XSCGHNKWSA-N

基因資訊

human ... OPRS1(10280)

生化／生理作用

Selective σ1 receptor agonist.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Parham Gharagozlou et al.
BMC pharmacology, 6, 3-3 (2006-01-26)
The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a human embryonic kidney cell system stably expressing only the mouse kappa-opioid receptors. Receptor activation was assessed by measuring
C Bucolo et al.
The Journal of pharmacology and experimental therapeutics, 289(3), 1362-1369 (1999-05-21)
In this study, we examined the presence of sigma1 and sigma2 sites in the rabbit iris-ciliary body by receptor binding and investigated their effects on intraocular pressure (IOP) in albino rabbits. The iris-ciliary body has binding sites for the sigma1-site
Mohamed S Amer et al.
British journal of pharmacology, 168(6), 1445-1455 (2012-11-06)
The Sigma-1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its ligands in relation to endogenous calcium events of endothelial cells and transient receptor potential (TRP) channels. Intracellular calcium and
Parham Gharagozlou et al.
BMC pharmacology, 3, 1-1 (2003-01-07)
The aim of the present study was to describe the activity of a set of opioid drugs, including partial agonists, in a cell system expressing only mu opioid receptors. Receptor activation was assessed by measuring the inhibition of forskolin-stimulated cyclic
R A Wilke et al.
The Journal of biological chemistry, 274(26), 18387-18392 (1999-06-22)
Recent work has indicated that sigma receptor ligands can modulate potassium channels. However, the only sigma receptor characterized at the molecular level has a novel structure unlike any other receptor known to modulate ion channels. This 26-kDa protein has a
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