跳轉至內容
Merck
全部照片(2)

重要文件

檢視所有文件

O4375

Sigma-Aldrich

催产素

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

同義詞:

α-多巴胺, 催产激素

登入查看組織和合約定價
全部照片(2)

About This Item

經驗公式（希爾表示法）:
C43H66N12O12S2
CAS號碼:
50-56-6
分子量：:
1007.19
Beilstein:
3586108
MDL號碼:
MFCD00076731
分類程式碼代碼:
51111800
PubChem物質ID:
24897994
NACRES:
NA.32
暫時無法取得訂價和供貨情況

生物源

synthetic

無菌

non-sterile

形狀

lyophilized powder

比活性

~15 IU/mg solid (Prepared from synthetic oxytocin)

溶解度

water: 10 mg/mL, clear, colorless

UniProt登錄號

P01178
P30559
P70536

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

InChI 密鑰

XNOPRXBHLZRZKH-DSZYJQQASA-N

基因資訊

human ... OXT(5020) , OXTR(5021)
rat ... Oxtr(25342)

尋找類似的產品？ 前往 產品比較指南

相關類別

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

一般說明

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13.[1][2] It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.[1]

應用

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.[3]

生化／生理作用

刺激子宫收缩和哺乳；增加Na+ 排泄；刺激子宫肌层GTP酶和磷脂酶 C。
Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation.[1] OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation.[2] Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity.[4] OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings.[5] Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).[6]

外觀

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000257585
0000272430
0000272429
0000257584
103H05241V

未看到正確版本？

如果您需要一個特定的版本，您可以透過批號來尋找特定憑證。

搜尋 COA

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Mia E Persson et al.
Hormones and behavior, 95, 85-93 (2017-08-03)
The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor
Margaret M Njoroge et al.
The American journal of tropical medicine and hygiene (2020-12-31)
Intranasal instillation of SE36, a malaria vaccine candidate antigen, in lactating BALB/c female mice resulted in the appearance of the antigen in breast milk as demonstrated by sandwich ELISA and Western blot. Pups born of immunologically naive mice and breastfed
Low oxytocin and melatonin levels and their possible role in the diagnosis and prognosis in Iraqi autistic children.
Abdulamir HA
Saudi Medical Journal, 37(1), 29-36 (2016)
Nitrergic modulation of vasopressin, oxytocin and atrial natriuretic peptide secretion in response to sodium intake and hypertonic blood volume expansion.
Ventura RR
Brazilian journal of medical and biological research, 35(9), 1101-1109 (2002)
The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization.
Rao VV
Cytogenetics and Cell Genetics, 61(4), 271-273 (1992)
查看所有相關論文

Questions

  1. I was wondering how many times Oxytocin lyophilized powder can be stored once it is diluted.

    1 answer

    1. The stability of Oxytocin concentrates stored at various temperatures for 48 months was evaluated regularly for biological activity on rat uteri. It was found that concentrates kept in a refrigerator showed no loss of oxytocin activity, while samples kept at 21°C showed a slight loss of activity (about 1.5% per year), and those at 30°C showed a marked loss of activity (about 10% per year). Similar results were obtained with dilute injections of oxytocin. The study concluded that oxytocin in solution has a shelf life of 3 years at 21°C but should not be exposed to higher temperatures (Nachtmann et al. 1981).

      In a simulation study conducted by WHO in collaboration with IDA Foundation, two batches of three brands of oxytocin ampoules were stored at different temperatures and samples were assayed for oxytocin content over a period of 2 years (Hogerzeil et al. 1993). Based on the results (Figure 2), WHO and IDA suggested the following guidelines for the shelf life of oxytocin injections at higher temperatures:

      - At 2°C- 8°C, shelf life of 3 years.
      - Below 21°C, shelf life of 2 years.
      - At 25°C, the shelf life is reduced to 1 year.
      - At 30°C, the shelf life is reduced to 6 months.
      - At 40°C transport maximum 1 week.

      Helpful?

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務