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Merck
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O1012

Sigma-Aldrich

油酰辅酶 A 锂盐

≥90% (HPLC)

同義詞:

顺式 -9-十八烯酰辅酶A

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About This Item

經驗公式(希爾表示法):
C39H68N7O17P3S
CAS號碼:
分子量::
1031.98
分類程式碼代碼:
41106305
NACRES:
NA.51

化驗

≥90% (HPLC)

儲存溫度

−20°C

應用

辅酶 A 作为酰基载体,乙酰辅酶 A 发挥作用。油酰辅酶 A 可能用于研究酰基辅酶 A:胆固醇酰基转移酶 1 (ACAT1) 等酶参与长链脂肪酸胆固醇酯化的特异性和动力学。

生化/生理作用

油酰辅酶A是一种重要的底物,对于1-烷基-2,3-二酰甘油(ADG)和哈德氏腺(HG)1-烷基-2,3-二酰甘油的超长链单不饱和脂肪酸的生物合成至关重要。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Catherine C Y Chang et al.
Biochemistry, 49(46), 9957-9963 (2010-10-23)
Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) is a membrane-bound enzyme utilizing long-chain fatty acyl-coenzyme A and cholesterol to form cholesteryl esters and coenzyme A. Previously, we had expressed tagged human ACAT1 (hACAT1) in CHO cells and purified it to homogeneity; however
Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2, 3-diacylglycerol
Miyazaki M, et al.
The Journal of Biological Chemistry, 276(42), 39455-39461 (2001)
Chengcheng Guan et al.
Nature communications, 11(1), 2478-2478 (2020-05-20)
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cholesterol to generate cholesteryl esters for cholesterol storage. SOAT1 is a target to treat several
Potential role of acyl-coenzyme A:cholesterol transferase (ACAT) Inhibitors as hypolipidemic and antiatherosclerosis drugs.
Leon C, Hill JS, Wasan KM.
Pharmaceut. Res., 22, 1578-1588 (2005)
Ta-Yuan Chang et al.
American journal of physiology. Endocrinology and metabolism, 297(1), E1-E9 (2009-01-15)
The enzymes acyl-coenzyme A (CoA):cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles

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