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Merck
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重要文件

N5655

Sigma-Aldrich

烟酸腺嘌呤二核苷酸磷酸 钠盐

≥92.5%

同義詞:

β-NAADP

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About This Item

經驗公式(希爾表示法):
C21H27N6O18P3 · xNa+
CAS號碼:
分子量::
744.39 (free acid basis)
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥92.5%

形狀

solid

儲存溫度

−20°C

SMILES 字串

[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OCC4O[C@@H]([C@@H](O)[C@H]4O)[n+]5cccc(c5)C(O)=O)[C@@H](O)[C@H]3OP(O)(O)=O

InChI

1S/C21H27N6O18P3.Na/c22-17-12-18(24-7-23-17)27(8-25-12)20-16(44-46(33,34)35)14(29)11(43-20)6-41-48(38,39)45-47(36,37)40-5-10-13(28)15(30)19(42-10)26-3-1-2-9(4-26)21(31)32;/h1-4,7-8,10-11,13-16,19-20,28-30H,5-6H2,(H6-,22,23,24,31,32,33,34,35,36,37,38,39);/q;+1/p-1/t10?,11-,13+,14-,15+,16-,19+,20-;/m1./s1

InChI 密鑰

KKCRODBDXQTAPI-NZNNTXIPSA-M

一般說明

注入细胞时NAADP诱导海胆卵中的Ca2 +释放。β它在ADP-核糖基环化酶的协助下可以由烟酰胺腺嘌呤二核苷酸磷酸盐(-NADP)酶促生产。[1]

應用

烟酸腺嘌呤二核苷酸磷酸钠盐已被用作注入未受精的卵和胚胎的激动剂。[2]

生化/生理作用

通过 IP 3 和环 ADP 核糖非依赖性机制有效激活细胞内 Ca 2+ 释放。

其他說明

注:不应与烟酰胺腺嘌呤二核苷酸磷酸 (NADP) 混淆。

準備報告

酶法制备 β-NADP + 类似物。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Patricia Gómez-Suaga et al.
Autophagy, 8(4), 692-693 (2012-03-24)
Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained
Parvinder K Aley et al.
The Journal of biological chemistry, 288(16), 10986-10993 (2013-03-08)
Nicotinic acid adenine dinucleotide phosphate (NAADP) is increasingly being demonstrated to be involved in calcium signaling in many cell types and species. Although it has been shown to play a role in smooth muscle cell contraction in several tissues, nothing
H C Lee et al.
The Journal of biological chemistry, 270(5), 2152-2157 (1995-02-03)
We have previously shown that alkaline treatment of NADP generates a derivative which can mobilize Ca2+ from sea urchin egg homogenates (Clapper, D. L., Walseth, T. F., Dargie, P. J., and Lee, H. C. (1987) J. Biol. Chem. 262, 9561-9568).
Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo
Eno C, et al.
Development (2018)
E N Chini et al.
The Journal of biological chemistry, 270(7), 3216-3223 (1995-02-17)
Transient fluxes of intracellular ionized calcium (Ca2+) from intracellular stores are integral components of regulatory signaling pathways operating in numerous biological regulations, including in early stages of egg fertilization. Therefore, we explored whether NADP, which is rapidly generated by phosphorylation

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