N3415

硝呋莫司

≥98% (HPLC)

• 同義詞: (RS)-3-methyl-N-[(1E)-(5-nitro-2-furyl)methylene]thiomorpholin-4-amine 1,1-dioxide, (±)-Nifurtimox, 3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide; 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide, BAY 2502, Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-,1,1-dioxide
• 經驗公式（希爾表示法）: C₁₀H₁₃N₃O₅S
• CAS號碼: 23256-30-6
• 分子量：: 287.29
• EC號碼: 245-531-0
• MDL號碼: MFCD00869254
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329818609
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: yellow to orange
• 溶解度: DMSO: ≥13 mg/mL
• 起源: Bayer
• 儲存溫度: room temp
• SMILES 字串: CC1CS(=O)(=O)CCN1\N=C\c2ccc(o2)[N+]([O-])=O
• InChI: 1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+
• InChI 密鑰: ARFHIAQFJWUCFH-IZZDOVSWSA-N

描述

一般說明

Nifurtimox acts as a hypoxia-activated cytotoxin, which specifically kills clonogenic tumor cells under hypoxic conditions.[1] It is used to treat Chagas disease and African trypanosomiasis.[2] Nifurtimox inhibits neuroblastoma and medulloblastoma cell growth.[3]

應用

Nifurtimox has been used in drug treatment in culture media.[1]

生化／生理作用

Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes.

Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. Nifurtimox was discovered empirically and its mechanism of action is unclear. It is believed that nifurtimox exerts its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen.

特點和優勢

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable