C-005

可待因-D₃ 溶液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 經驗公式（希爾表示法）: C₁₈H₁₈D₃NO₃
• CAS號碼: 70420-71-2
• 分子量：: 302.38
• EC號碼: 200-659-6
• MDL號碼: MFCD01075373
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329774759
• NACRES: NA.24

屬性

• 等級: certified reference material
• 品質等級: 300
• 形狀: liquid
• 特點: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• 濃度: 100 μg/mL in methanol
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: forensics and toxicology
• 格式: single component solution
• 儲存溫度: −20°C
• SMILES 字串: [2H]C([2H])([2H])N1CC[C@]23[C@H]4Oc5c(OC)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O)c35
• InChI: 1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1/i1D3
• InChI 密鑰: OROGSEYTTFOCAN-SBGSAQJDSA-N

描述

一般說明

可待因-D₃是一种稳定标记的内标物，适用于包括疼痛处方监测、法医分析、临床毒理学、尿液药物测试或同位素稀释方法在内的许多LC/MS或GC/MS试验应用。可待因是一种具有镇痛、镇咳和镇静作用的鸦片制剂，是鸦片中第二大主要生物碱。由于鸦片类药物被归类为受控物质，Cerilliant都是以免DEA溶液的形式提供绝大多数鸦片标准品的，以提高便利性。

應用

• A Novel Bioanalytical Method: This research introduces a novel bioanalytical method for determining opioids in blood and pericardial fluid, highlighting the importance of Codeine-D₃ as a reliable internal standard for precise quantification in forensic and clinical settings (Ferreira et al., 2020).


• GC-Triple Quadrupole MS Assay: A gas chromatography-triple quadrupole mass spectrometry assay developed for quantifying opiates in human blood samples employs Codeine-D₃, demonstrating its utility in enhancing detection sensitivity and accuracy in toxicological analyses (Saad et al., 2019).


• Comparison of Mass Analyzers: This study compares different mass analyzers for quantifying opioids in human plasma, where Codeine-D₃ serves as a critical component for ensuring measurement consistency across platforms, facilitating comprehensive pharmacokinetic studies (Viaene et al., 2016).


• Electrospray LC-MS Method: An electrospray LC-MS method with solid-phase extraction is employed for accurate determination of morphine, codeine, and their glucuronides in urine, with Codeine-D₃ used to improve the reliability of drug testing protocols (Svensson et al., 2007).


• Validation of LC-MS/MS for Opiate Confirmation: This study validates a direct injection electrospray LC-MS/MS technique for confirming opiates in urine, where Codeine-D₃ is integral for certifying the method′s efficacy, enhancing both forensic and clinical drug testing (Gustavsson et al., 2007).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes,Central nervous system
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup