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N0267

Sigma-Aldrich

(±)-尼古丁

≥99% (TLC), liquid

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About This Item

經驗公式（希爾表示法）:
C10H14N2
CAS號碼:
22083-74-5
分子量：:
162.23
Beilstein:
82108
MDL號碼:
MFCD00065370
分類程式碼代碼:
12352210
eCl@ss:
39151701
PubChem物質ID:
24897418
NACRES:
NA.77

品質等級

200

化驗

≥99% (TLC)

形狀

liquid

光學活性

[α]25/D 0°(lit.)

顏色

yellow

溶解度

ethanol: 50 mg/mL

密度

1.02 g/mL at 25 °C (lit.)

SMILES 字串

CN1CCCC1c2cccnc2

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3

InChI 密鑰

SNICXCGAKADSCV-UHFFFAOYSA-N

基因資訊

human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137)
rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)

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應用

(±)-Nicotine has been used:
  • as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
  • as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
  • as a test compound to study its effects on fibril formation

生化／生理作用

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.
Prototype nicotinic acetylcholine receptor agonist.

訊號詞

Danger

危險分類

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

213.8 °F - closed cup

閃點（°C）

101 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析證明 (COA)

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