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M3512

Sigma-Aldrich

(±)-咪康唑 硝酸盐

imidazole antibiotic

同義詞:

1-(2,4-二氯-β-[(2,4-二氯苄基)氧] 苯乙基 ] 咪唑

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About This Item

經驗公式(希爾表示法):
C18H14Cl4N2O · HNO3
CAS號碼:
分子量::
479.14
EC號碼:
MDL號碼:
分類程式碼代碼:
51102829
eCl@ss:
39161001
PubChem物質ID:
NACRES:
NA.85

品質等級

光學活性

[α]/D ±0.10° (Specific Rotation (BP))

顏色

white to off-white

抗生素活性譜

fungi
mycobacteria

作用方式

enzyme | inhibits

SMILES 字串

ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O

InChI

1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)

InChI 密鑰

MCCACAIVAXEFAL-UHFFFAOYSA-N

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一般說明

化学结构:咪唑

應用

咪康唑是咪唑类抗真菌药,可局部用药和静脉输注。它用于抑制细胞色素 P450 和研究自动发光为基础的细胞色素 P450 谱

生化/生理作用

咪康唑与 14-α 相互作用脱甲基酶,一种麦角固醇生物合成所必需的细胞色素 P-450 酶。麦角固醇的抑制导致细胞通透性增加引起细胞内容物渗漏。咪康唑还可能抑制内源性呼吸,与细胞膜中的磷脂相互作用,抑制酵母菌转化为菌丝形式,抑制嘌呤摄取,干扰甘油三酯和磷脂的生物合成。

準備報告

略溶于甲醇,微溶于乙醇。在水中极微溶解。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

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Automated Luminescence-Based Cytochrome P450 Profiling Using a Simple, Elegant Robotic Platform
Brad Larson, Peter Banks, et al.
Journal of the Association for Laboratory Automation, 16, 47-55 (2011)
Francis X Cunningham et al.
Eukaryotic cell, 6(3), 533-545 (2006-11-07)
Cyanidioschyzon merolae is considered to be one of the most primitive of eukaryotic photosynthetic organisms. To obtain insights into the origin and evolution of the pathway of carotenoid biosynthesis in eukaryotic plants, the carotenoid content of C. merolae was ascertained
Ali Reza Khosravi et al.
Foodborne pathogens and disease, 9(7), 674-679 (2012-06-14)
The purpose of the present study was to evaluate and assess the capability of Zataria multiflora, Geranium herbarium, and Eucalyptus camaldolensis essential oils in treating Saprolegnia parasitica-infected rainbow (Oncorhynchus mykiss) trout eggs. A total of 150 infected eggs were collected
Sónia P M Ventura et al.
Ecotoxicology and environmental safety, 83, 55-62 (2012-06-30)
A wide range of ionic liquids (ILs), containing a diverse set of cations, anions and alkyl chain lengths, was screened for their antimicrobial activity toward four microorganisms, Escherichia coli CCT-0355, Staphylococcus aureus ATCC-6533, Fusarium sp. LM03 and Candida albicans ATCC-76645.
V M Litvinov et al.
Molecular pharmaceutics, 9(10), 2924-2932 (2012-08-22)
The use of hot-melt extrusion for preparing homogeneous API-excipient mixtures is studied for miconazole-PEG-g-PVA [poly(ethylene glycol)-poly(vinyl alcohol) graft copolymer] solid dispersions with a 5 cm(3) table-top, twin-screw corotating microcompounder (DSM Xplore). Phase behavior of PEG-g-PVA, miscibility of miconazole in PEG-g-PVA

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