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重要文件

L6004

Sigma-Aldrich

林可霉素 盐酸盐

≥90% (TLC)

同義詞:

Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside 盐酸盐, 林可霉素 盐酸盐

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About This Item

經驗公式(希爾表示法):
C18H34N2O6S · HCl
CAS號碼:
分子量::
443.00
Beilstein:
4171650
EC號碼:
MDL號碼:
分類程式碼代碼:
51284507
PubChem物質ID:
NACRES:
NA.85
暫時無法取得訂價和供貨情況

化驗

≥90% (TLC)

效力

800-900 units per mg

顏色

white to faint yellow

溶解度

H2O: soluble 50 mg/mL

抗生素活性譜

Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

InChI 密鑰

POUMFISTNHIPTI-BOMBIWCESA-N

尋找類似的產品? 前往 產品比較指南

一般說明

化学结构:大环内酯

應用

盐酸林可霉素是一种抗生素,用于研究蛋白质合成抑制、细菌抗生素耐药性以及蛋白质和表面活性剂的结合 [1][2] 它是由 链霉菌 var. Lincolnensis 产生。

生化/生理作用

作用方式:林可霉素可通过在23S rRNA的肽基转移酶环区域内形成交联来抑制细菌蛋白质的合成。†

抗菌谱:盐酸林可霉素对革兰氏阳性菌有效。

準備報告

该产品在水中的溶解度为50 mg/mL,产生澄清无色的溶液。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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H Malke et al.
Antimicrobial agents and chemotherapy, 19(1), 91-100 (1981-01-01)
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at
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RNA editing is one of the post-transcriptional processes that commonly occur in plant plastids and mitochondria. In Arabidopsis, 34 C-to-U RNA editing events, affecting transcripts of 18 plastid genes, have been identified. Here, we examined the editing and expression of
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A new type of multi-color PAM chlorophyll fluorometer (Schreiber et al. 2012) was applied for measurements of photodamage to photosystem II (PS II) in optically thin suspensions of Chlorella (200 μg Chl l(-1)) in the presence of 1 mM lincomycin.

文章

蛋白质合成是一个复杂、多步骤过程,涉及到很多酶以及构象排列。但是,阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

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