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重要文件

L4268

Sigma-Aldrich

脂多糖 来源于肺炎克雷伯氏杆菌

Lipopolysaccharides from Klebsiella pneumoniae

purified by phenol extraction

同義詞:

LPS

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About This Item

MDL號碼:
MFCD00131520
分類程式碼代碼:
12352201
NACRES:
NA.25
暫時無法取得訂價和供貨情況

生物源

bacterial (Klebsiella pneumoniae)

品質等級

200

形狀

lyophilized powder

純化經由

phenol extraction

雜質

<3% Protein (Lowry)

顏色

white to faint yellow

溶解度

water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow

運輸包裝

ambient

儲存溫度

2-8°C

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相關類別

一般說明

该产品是从肺炎克雷伯菌通过苯酚提取而来。源菌株是 ATCC 15380。

生化／生理作用

脂多糖（LPS）位于膜的外层，并且在非包封菌株中暴露在细胞表面上。它们有助于保持外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。

準備報告

本产品可溶于水（5mg/ml）或细胞培养基（1mg/ml），形成浑浊的淡黄色溶液。经过涡旋并升温至 70-80 oC 后，在盐水中可获得浓度更高、但仍然混浊的溶液（20mg/ml）。脂多糖分子在每种溶剂中都会形成胶束。在水和磷酸盐缓冲液中形成浑浊的溶液。在有机溶剂中也不会更清澈。在甲醛中形成具有漂浮物的浑浊悬浮液，而在水中则产生均匀浑浊的溶液。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000410664
0000410664
0000362509
0000312728
0000312727

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Nora S Wolff et al.
Intensive care medicine experimental, 8(1), 47-47 (2020-08-26)
The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendors can influence murine models of pulmonary lipopolysaccharide (LPS) inflammation
Teresa García-Lezana et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(3), 927-937 (2016-05-08)
Hepatic encephalopathy has traditionally been considered a reversible disorder. However, recent studies suggested that repeated episodes of hepatic encephalopathy cause persistent impairment leading to neuronal loss. The aims of our study were the development of a new animal model that
Jinling Zhang et al.
Biosensors & bioelectronics, 99, 312-317 (2017-08-09)
We report a smartphone label-free biosensor platform based on grating-coupled surface plasmon resonance (GC-SPR). The sensor system relies on the smartphone's built-in flash light source and camera, a disposable sensor chip with Au diffraction grating and a compact disk (CD)
C Arnold Spek et al.
Cells, 10(9) (2021-09-29)
CCAAT/enhancer-binding protein delta (C/EBPδ) is a member of the C/EBP family of transcription factors. According to the current paradigm, C/EBPδ potentiates cytokine production and modulates macrophage function thereby enhancing the inflammatory response. Remarkably, however, C/EBPδ deficiency does not consistently lead
Max C Jacobs et al.
PloS one, 15(11), e0241748-e0241748 (2020-11-05)
An increasing body of evidence is indicating that the gut microbiota modulates pulmonary inflammatory responses. This so-called gut-lung axis might be of importance in a whole spectrum of inflammatory pulmonary diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary
查看所有相關論文

文章

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

相關內容

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

脂多醣體

脂多醣 (LPS) 是革蘭氏陰性細菌的主要成分，對微生物研究非常重要。

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Questions

  1. Is the product LPS from K. pneumoniae Cat N L4268 Ultrapure? As prevention to minimisation effect of the mixture in cell culture

    1 answer

    1. This product is purified by phenol extraction and is not considered ‘Ultrapure’. Currently, the term ‘Ultrapure’ is not assigned to any of the LPS products. However, the method of purification is highly indicative of the type and amount of contaminants that may be present. Of the various methods of preparation and purification available, the most pure products are those purified by ion exchange chromatography followed by those purified by gel filtration. Unfortunately, a chromatography purified version of LPS from Klebsiella is not currently available.
      Please see the link below for more information on the results of this type of purification.
      https://www.sigmaaldrich.com/technical-documents/technical-article/research-and-disease-areas/cell-signaling/lipopolysaccharides

      Please see the link below to review LPS products sorted by the purification method:
      https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/immunology-research/lipopolysaccharides-for-research

      Please see the following link to review the general handling and usage information available for LSP products:
      https://www.sigmaaldrich.com/technical-documents/protocol/clinical-testing-and-diagnostics-manufacturing/bacteriology/lipopolysaccharides

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