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重要文件

L4040

Sigma-Aldrich

乳铁蛋白 人

recombinant, expressed in rice, Partially iron saturated, ≥90% (SDS-PAGE)

同義詞:

Growth-inhibiting protein 12, Lactotransferrin, Talalactoferrin

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.61
暫時無法取得訂價和供貨情況

生物源

human

重組細胞

expressed in rice

化驗

≥70% protein basis (Bradford)
≥90% (SDS-PAGE)

形狀

powder

技術

microbiological culture: suitable

溶解度

H2O: soluble 10 mg/mL

UniProt登錄號

儲存溫度

2-8°C

基因資訊

human ... LTF(4057)

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應用

使用乳铁蛋白在铁限制培养基中培养变形链球菌[1] 用于测试乳铁蛋白在体外是否阻碍上皮细胞黏附 [2] 同时用于测试血液细胞因子浓度对急性肺炎的诊断价值。[3]

生化/生理作用

乳铁蛋白是一种铁结合蛋白。在结构上与血浆铁转运蛋白转铁蛋白相似;但是乳铁蛋白对铁的亲和力要高得多(250 倍)。在初乳中含量非常丰富,少量也可见于泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中。由粘膜上皮和中性粒细胞组成,在炎症刺激下由这些细胞释放。细菌的生长被其隔离铁的能力所抑制,也通过其 N 端与脂多糖结合使细菌细胞壁通透性增加。乳铁蛋白可以通过与病毒包膜蛋白紧密结合来抑制病毒感染。这通过阻断结合域阻止了细胞与病毒的融合。乳铁蛋白似乎部分通过刺激中性粒细胞激活剂白细胞介素-8 的释放来激活宿主防御系统。还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Chuang Guo et al.
Food & function, 11(8), 7183-7196 (2020-08-07)
Lactoferrin (Lf), an iron-binding glycoprotein, has been shown to possess antioxidant and anti-inflammatory properties and exert modulatory effects on lipid homeostasis and non-alcoholic fatty liver disease (NAFLD), but our understanding of its regulatory mechanisms is limited and inconsistent. We used
Thuy Nguyen Thi Dao et al.
Journal of extracellular vesicles, 11(2), e12195-e12195 (2022-02-22)
Cancer cell-derived extracellular vesicles (EVs) are promising biomarkers for cancer diagnosis and prognosis. However, the lack of rapid and sensitive isolation techniques to obtain EVs from clinical samples at a sufficiently high yield limits their practicability. Chimeric nanocomposites of lactoferrin
Qingsheng Kong et al.
Molecular and cellular biochemistry, 406(1-2), 293-299 (2015-05-20)
The metalloprotease lethal factor (LF) from Bacillus anthracis plays a vital role in anthrax toxin action, and thus becomes a target for anti-anthrax therapy. Following the guidelines based on existing metalloprotease inhibitors, we designed a 'first-generation' LF inhibitor R9LF-1. This
P Kragsbjerg et al.
Thorax, 50(12), 1253-1257 (1995-12-01)
The role of cytokines in the pathogenesis of pneumonia is still poorly understood. In a previous study the diagnostic value of measuring blood concentrations of interleukin 6 and interferon gamma was established. In the present study the value of blood
Mingi Kim et al.
mBio, 12(5), e0224821-e0224821 (2021-09-15)
The human pathogen Acinetobacter baumannii produces and utilizes acinetobactin for iron assimilation. Although two isomeric structures of acinetobactin, one featuring an oxazoline (Oxa) and the other with an isoxazolidinone (Isox) at the core, have been identified, their differential roles as

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