Following reconstitution at 25 mg/mL in 0.1 M Acetic acid, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C. The stability of dilute solutions has not been determined, however, Bradykinin fragment 1 - 7, (B4181) is part of a set of standards for Maldi-MS calibration (MSCAL1). In this application, the solution is diluted to 10 pmol/uL and stored at -20°C for 1 month. One may infer that dilute solutions of the whole molecule would be comparably stable when diluted and stored frozen.
推薦產品
等級
for analytical purposes
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white
溶解度
0.1 M acetic acid: 25 mg/mL, clear, colorless
UniProt登錄號
儲存溫度
−20°C
SMILES 字串
N2([C@@H](CCC2)C(=O)NCC(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CO)C(=O)N3[C@@H](CCC3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N
InChI
1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
InChI 密鑰
QXZGBUJJYSLZLT-FDISYFBBSA-N
基因資訊
human ... KNG1 (includes EG:3827)
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Amino Acid Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
應用
生化／生理作用
激活痛觉受体；引起平滑肌收缩；激活 Ca2+ 依赖性一氧化氮合成酶；增加毛细血管通透性。
缓激肽是一种促炎肽，通过 G-蛋白质偶联受体进行作用。它活化鞘脂类的代谢。经缓激肽处理的成纤维细胞的神经酰胺分泌量会有快速而重大的增长，随后鞘氨醇含量也会短暂上升。这种肽也会通过使中性糖脂快速移动来增加细胞的神经酰胺含量。缓激肽在体液和电解质平衡的调节、平滑肌收缩、血管舒张和毛细血管通透性方面都发挥着重要的作用。缓激肽增效剂本身不具有缓激肽活性，但能增强缓激肽的活性。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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How should a solution of bradykinin acetate salt in 0.1M acetic acid be stored? Can it be further diluted in an aqueous buffer?
1 answer-
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