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重要文件

H1753

Sigma-Aldrich

肼屈嗪 盐酸盐

同義詞:

1-肼基二氮杂萘 盐酸盐

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About This Item

經驗公式(希爾表示法):
C8H8N4 · HCl
CAS號碼:
分子量::
196.64
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

化驗

≥99% (TLC)

形狀

powder

mp

273 °C

溶解度

water: 50 mg/mL

SMILES 字串

Cl[H].N\N=C1/N=NC=C2C=CC=CC12

InChI

1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;

InChI 密鑰

SECXUXOCDLQOBI-MKFZHGHUSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

應用

盐酸肼屈嗪已用于:
  • 研究其作为血管扩张药,对大鼠幼鼠T细胞频率升高相关高血压的影响[1]
  • 研究其作为氨基脲敏感性胺氧化酶(SSAO)抑制剂,对心肌缺血再灌注(I/R)损伤的影响[2]
  • 研究其作为血管扩张药,对胰岛素分泌和葡萄糖耐受的影响[3]

生化/生理作用

抑制DNA甲基转移酶并调节基因表达的表观遗传调控。非选择性MAO-A/B抑制剂;降压药;氨基脲敏感性胺氧化酶抑制剂。
盐酸肼屈嗪(Hydralazine)可用于治疗心力衰竭和高血压。[4]

特點和優勢

该化合物收录于受体分类和信号转导手册的《多巴胺和去甲肾上腺素代谢》页面。想要浏览手册的其他页面, 请单击此处

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Nadine S Sauter et al.
Diabetes, 64(4), 1273-1283 (2014-10-30)
Pathological activation of the renin-angiotensin system (RAS) is associated with the metabolic syndrome, and the new onset of type 2 diabetes can be delayed by RAS inhibition. In animal models of type 2 diabetes, inhibition of the RAS improves insulin
Ruijia Feng et al.
Gut microbes, 16(1), 2390164-2390164 (2024-08-18)
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms remain unclear. In this study, we established a NAFLD mouse model
Edmond A Rogers et al.
Scientific reports, 12(1), 11838-11838 (2022-07-14)
While clinical observations have confirmed a link between the development of neurodegenerative diseases and traumatic brain injuries (TBI), there are currently no treatments available and the underlying mechanisms remain elusive. In response, we have developed an in vitro pendulum trauma
Urmila P Kodavanti et al.
Toxicology and applied pharmacology, 268(2), 232-240 (2013-02-19)
Exposure to diesel exhaust (DE) and associated gases is linked to cardiovascular impairments; however, the susceptibility of hypertensive individuals is poorly understood. The objectives of this study were (1) to determine cardiopulmonary effects of gas-phase versus whole-DE and (2) to
Mara Colzani et al.
ChemMedChem, 11(16), 1778-1789 (2016-02-19)
Reactive carbonyl species (RCS) are endogenous or exogenous byproducts involved in the pathogenic mechanisms of different oxidative-based disorders. Detoxification of RCS by carbonyl quenchers is a promising therapeutic strategy. Among the most studied quenchers are aminoguanidine, hydralazine, pyridoxamine, and carnosine;

文章

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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