F4381

呋塞米

≥98% (HPLC), powder, NKCC symporter inhibitor

• 同義詞: 4-氯-N-呋喃基-5-氨磺酰邻氨基苯甲酸, 5-(氨基磺酰基)-4-氯-2-([2-呋喃甲基]氨基)苯甲酸
• 經驗公式（希爾表示法）: C₁₂H₁₁ClN₂O₅S
• CAS號碼: 54-31-9
• 分子量：: 330.74
• EC號碼: 200-203-6
• MDL號碼: MFCD00010549
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24277714
• NACRES: NA.77

屬性

• product name: 呋塞米,
• 生物源: synthetic (organic)
• 化驗: ≥98% (HPLC)
• 形狀: powder
• mp: 220 °C (dec.) (lit.)
• 溶解度: acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
• 起源: Sanofi Aventis
• 儲存溫度: room temp
• SMILES 字串: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
• InChI: 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
• InChI 密鑰: ZZUFCTLCJUWOSV-UHFFFAOYSA-N
• 基因資訊: human ... ALB(213) , CYP1A2(1544) , SLC12A1(6557)

描述

一般說明

Furosemide is a an ototoxic high-ceiling diuretic.

應用

Furosemide has been used:

• to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
• to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
• as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

生化／生理作用

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

抑制肾脏中离子的协同运输。

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H360FD
• 防範說明: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• 危險分類: Acute Tox. 4 Oral - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges