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G8272

Galanin rat

Name: Galanin rat
Brand: SIGMA

≥97% (HPLC), powder

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About This Item

經驗公式（希爾表示法）:

C₁₄₁H₂₁₁N₄₃O₄₁

CAS號碼:

114547-31-8

分子量：:

3164.45

MDL號碼:

MFCD00133354

分類程式碼代碼:

12352200

PubChem物質ID:

24895336

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Sigma-Aldrich

L2630

脂多糖来源于大肠杆菌 0111:B4

Sigma-Aldrich

C5138

胶原酶来源于溶组织梭菌

Sigma-Aldrich

L4391

脂多糖来源于大肠杆菌 0111:B4

Sigma-Aldrich

C9891

胶原酶来源于溶组织梭菌

Roche

10104159001

DNase I

Sigma-Aldrich

C0130

胶原酶来源于溶组织梭菌

Supelco

PHR1251

氯化胆碱

Sigma-Aldrich

H3393

肝素钠盐来源于猪肠粘膜

Roche

11284932001

DNase I

Sigma-Aldrich

N5017

Neuropeptide Y human

化驗

≥97% (HPLC)

形狀

powder

成份

Peptide content, ≥65%

UniProt登錄號

P10683

儲存溫度

−20°C

SMILES 字串

CCC(C)C(NC(=O)C(C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C2CCCN2C(=O)CNC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc3ccc(O)cc3)NC(=O)CNC(=O)C(C)NC(=O)C(CO)NC(=O)C(CC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(Cc4c[nH]c5ccccc45)NC(=O)CN)C(C)O)C(=O)NC(CC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(Cc6cnc[nH]6)C(=O)NC(CCCNC(N)=N)C(=O)NC(CO)C(=O)NC(Cc7ccccc7)C(=O)NC(CO)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(Cc8cnc[nH]8)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(N)=O

InChI

1S/C141H211N43O41/c1-15-71(10)113(139(224)177-100(52-112(199)200)132(217)173-97(49-105(144)191)129(214)171-96(48-81-57-151-66-159-81)128(213)166-86(30-23-37-152-141(147)148)122(207)178-102(62-186)136(221)169-92(43-76-25-17-16-18-26-76)127(212)180-103(63-187)137(222)174-99(51-111(197)198)131(216)165-85(29-21-22-36-142)121(206)170-94(46-79-55-149-64-157-79)120(205)155-59-109(195)163-88(40-68(4)5)133(218)182-114(74(13)188)116(146)201)181-118(203)73(12)161-123(208)95(47-80-56-150-65-158-80)175-138(223)104-31-24-38-184(104)110(196)60-156-119(204)87(39-67(2)3)167-124(209)89(41-69(6)7)168-126(211)91(44-77-32-34-82(190)35-33-77)164-108(194)58-154-117(202)72(11)160-135(220)101(61-185)179-130(215)98(50-106(145)192)172-125(210)90(42-70(8)9)176-140(225)115(75(14)189)183-134(219)93(162-107(193)53-143)45-78-54-153-84-28-20-19-27-83(78)84/h16-20,25-28,32-35,54-57,64-75,85-104,113-115,153,185-190H,15,21-24,29-31,36-53,58-63,142-143H2,1-14H3,(H2,144,191)(H2,145,192)(H2,146,201)(H,149,157)(H,150,158)(H,151,159)(H,154,202)(H,155,205)(H,156,204)(H,160,220)(H,161,208)(H,162,193)(H,163,195)(H,164,194)(H,165,216)(H,166,213)(H,167,209)(H,168,211)(H,169,221)(H,170,206)(H,171,214)(H,172,210)(H,173,217)(H,174,222)(H,175,223)(H,176,225)(H,177,224)(H,178,207)(H,179,215)(H,180,212)(H,181,203)(H,182,218)(H,183,219)(H,197,198)(H,199,200)(H4,147,148,152)

InChI 密鑰

JHQDYHHNJBOXKP-UHFFFAOYSA-N

基因資訊

rat ... Gal(29141)

Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Ile-Asp-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-His-Gly-Leu-Thr-NH₂

生化／生理作用

Co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca²⁺ channels; linked to behavioral and cognitive deficits in Alzheimer′s disease.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Galanin is a paracrine inhibitor of gonadotroph function in the female rat.

J F Todd et al.

Endocrinology, 139(10), 4222-4229 (1998-09-29)

Recent evidence suggests that pituitary galanin synthesized in the lactotroph is a paracrine regulator of lactotroph proliferation and PRL secretion and that these effects are mediated via a pituitary-specific galanin receptor, GAL-R2(orig.). At this receptor subtype, the galanin fragment 3-29

Pharmacological characterization of the contractile effects of galanin (1-29)-NH2, galantide and galanin (1-14)-(alpha-aminobutyric acid8)scyliorhinin-I in the rat gastric fundus.

R Korolkiewicz et al.

Fundamental & clinical pharmacology, 11(6), 576-583 (1997-01-01)

Porcine galanin (1-29)-NH2, galantide (M15) and galanin (1-14)-(alpha-aminobutyric acid8)-scyliorhinin-I used in concentrations of 300, 1,000 and 3,000 nM respectively caused contractions of rat fundus strips. The contractile responses to galanin(1-29)-NH2 were not modified by atropine (10 microM), guanethidine (10 microM)

The GalR2 galanin receptor mediates galanin-induced jejunal contraction, but not feeding behavior, in the rat: differentiation of central and peripheral effects of receptor subtype activation.

S Wang et al.

FEBS letters, 434(3), 277-282 (1998-09-22)

The neuropeptide galanin mediates a diverse array of physiological functions through activation of specific receptors. Roles of the three recently cloned galanin receptors (GalRs) in rat intestinal contraction and food intake were examined using GalR-selective ligands and the results were

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors.

Rachel P Tillage et al.

Brain structure & function, 225(2), 785-803 (2020-02-18)

Accumulating evidence indicates that disruption of galanin signaling is associated with neuropsychiatric disease, but the precise functions of this neuropeptide remain largely unresolved due to lack of tools for experimentally disrupting its transmission in a cell type-specific manner. To examine

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重要文件

Galanin rat

≥97% (HPLC), powder

About This Item

推薦產品

屬性

化驗

形狀

成份

UniProt登錄號

儲存溫度

SMILES 字串

InChI

InChI 密鑰

基因資訊

描述

Amino Acid Sequence

生化／生理作用

安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

個人防護裝備

文件

分析證明 (COA)

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