推薦產品
生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥97% (SDS-PAGE and N-terminal analysis)
形狀
lyophilized powder
效力
0.1-15.0 ng/mL
分子量
27 kDa
包裝
pkg of 50 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... FGF5(2250)
應用
Fibroblast growth factor-5 human has been used for the induction of differentiation in E14Tg2a and 46C parental mouse ES (embryonic stem) cell lines, Fgf4+/- (clone 342) ,Fgf4-/- (clone FD6) ES cells and Erk2+/- ES cells and Erk2-/- ES cell lines.
生化／生理作用
FGF5 (fibroblast growth factor 5) regulates hair growth cycle, and its inactivation in mice leads to angora phenotype. In the peripheral nervous system, it acts as a muscle-derived trophic factor for motor neurons. In vivo it demonstrates neurotrophic activity, and in vitro it influences astroglial characteristics. It functions as an oncogene in glioblastoma due to its autocrine and paracrine functions. Its expression is elevated in human astrocytic brain tumours, which is linked to increased malignancy. It causes the regression of hair follicles, and thus, controls the length of hair in humans. It might have potential as a therapeutic target to control the growth of eyelashes.
外觀
Lyophilized from a 0.2 μm filtered solution in 10mM MOPS, 50 mM NaSO4, 0.5 mM EDTA, 0.5 mM DTT and 5% trehalose, pH 7.0 containing 50 μg BSA per 1 μg cytokine.
分析報告
The biological activity is tested in culture with quiescent NR6R-3T3 fibroblasts.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Claire A Higgins et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(29), 10648-10653 (2014-07-06)
Mechanisms that regulate the growth of eyelashes have remained obscure. We ascertained two families from Pakistan who presented with familial trichomegaly, or extreme eyelash growth. Using a combination of whole exome sequencing and homozygosity mapping, we identified distinct pathogenic mutations
Fibroblast growth factors (FGFs).
Vainikka, S., et al. et al.
Guidebook to Cytokines and Their Receptors, 214-214 (1994)
M Klagsbrun
Progress in growth factor research, 1(4), 207-235 (1989-01-01)
This article summarizes the structural and biological properties of the family of fibroblast growth factors (FGF). Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. bFGF and aFGF are potent modulators of cell proliferation
S Allerstorfer et al.
Oncogene, 27(30), 4180-4190 (2008-03-26)
Fibroblast growth factor 5 (FGF5) is widely expressed in embryonic but scarcely in adult tissues. Here we report simultaneous overexpression of FGF5 and its predominant high-affinity receptor (FGFR1 IIIc) in astrocytic brain tumour specimens (N=49) and cell cultures (N=49). The
Tilo Kunath et al.
Development (Cambridge, England), 134(16), 2895-2902 (2007-07-31)
Pluripotent embryonic stem (ES) cells must select between alternative fates of self-replication and lineage commitment during continuous proliferation. Here, we delineate the role of autocrine production of fibroblast growth factor 4 (Fgf4) and associated activation of the Erk1/2 (Mapk3/1) signalling
文章
Fibroblast growth factors in cell culture and various growth factors for your research
細胞培養中的成纖維細胞生長因子和各種生長因子，供您的研究使用
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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