推薦產品
生物源
synthetic (organic)
無菌
non-sterile
化驗
≥98% (HPLC)
形狀
powder
技術
inhibition assay: suitable
mp
238-240 °C (lit.)
溶解度
chloroform: methanol (1:1): 40 mg/mL, clear, colorless to faintly yellow
運輸包裝
ambient
儲存溫度
room temp
SMILES 字串
C[C@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]1CCC2=O
InChI
1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1
InChI 密鑰
WKRLQDKEXYKHJB-HFTRVMKXSA-N
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生化／生理作用
Equilin is the Mare estrogen and is majorly used in multi-estrogen drugs for hormone replacement therapy.[1] It is synthesized in the microsomes of mare placenta.[2] It mediates estrogen receptor β (ERβ) expression resulting in the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) which favors monocytes adhesion in atherosclerosis.[3] In vitro equilin inhibits 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that catalyzes the conversion of estrone to 17β-estradiol.[4]
訊號詞
Warning
危險聲明
危險分類
Carc. 2 - Lact. - Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
客戶也查看了
Equilin and equilenin biosynthesis. Stereochemistry of aromatization of 3-hydroxy-3, 5, 7-androstatrien-17-one by horse placenta
Mitsuteru N and Yoshio O
Journal of Steroid Biochemistry, 26(1), 137-143 (1987)
Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1, 3, 5, 7-tetraen-17-one (equilin) and NADP+
Sawicki MW, et al.
Proceedings of the National Academy of Sciences of the USA, 96(3), 840-845 (1999)
Equilin
Handbook of Hormones, 582-582 (2016)
Manabu Yasui et al.
Carcinogenesis, 24(5), 911-917 (2003-05-29)
Increased incidence of breast, ovarian and endometrial cancers are observed in women receiving estrogen replacement therapy (ERT). Equilin and equilenin are the major components of the widely prescribed drug used for ERT. These equine estrogens are metabolized primarily to 4-hydroxyequilin
Dieldrich S Bermudez et al.
International journal of andrology, 35(3), 397-406 (2012-05-23)
There is growing concern of exposure of fish, wildlife and humans to water sources contaminated with oestrogens and the potential impact on reproductive health. Environmental oestrogens can come from various sources including concentrated animal feedlot operations (CAFO), municipal waste, agricultural
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