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重要文件

E7138

Sigma-Aldrich

乙琥胺

同義詞:

2-乙基-2-甲基琥珀酰亚胺

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About This Item

經驗公式(希爾表示法):
C7H11NO2
CAS號碼:
分子量::
141.17
EC號碼:
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.77
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品質等級

溶解度

ethanol: 100 mg/mL

SMILES 字串

O=C1NC(CC1(C)CC)=O

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI 密鑰

HAPOVYFOVVWLRS-UHFFFAOYSA-N

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應用

乙琥胺已被用于:
  • 证实其对大鼠棘波放电(SWD)的作用[1]
  • 考察其对野生型斑马鱼幼体自发运动和焦虑相关趋触性行为的影响[2]
  • 作为模型药物体内治疗癫痫症(4)

生化/生理作用

乙琥胺是一种抗惊厥药[3],同时也是T型钙通道拮抗剂。它可防止失神发作中的棘波放电。[1]

特點和優勢

该化合物在受体分类和信号转导手册的钙通道页面上有重点介绍。如需浏览其他手册页面,请点击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Self-assembling PVA-F127 thermosensitive nanocarriers with highly sensitive magnetically-triggered drug release for epilepsy therapy in vivo
Huang HY, et al.
Journal of Materials Chemistry, 22(17), 8566-8573 (2012)
Behavioural responses of zebrafish larvae to acute ethosuximide exposure
Ji Y, et al.
Behavioural Pharmacology, 28(6), 428-440 (2017)
N Leresche et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(13), 4842-4853 (1998-06-23)
The action of ethosuximide (ETX) on Na+, K+, and Ca2+ currents and on tonic and burst-firing patterns was investigated in rat and cat thalamic neurons in vitro by using patch and sharp microelectrode recordings. In thalamocortical (TC) neurons of the
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
Pearce PS, et al.
Epilepsy & Behavior : E&B, 32, 121-131 (2014)
Shang-Der Chen et al.
Epilepsia, 52(7), 1311-1318 (2011-07-07)
Generalized absence seizures are characterized by bilateral spike-wave discharges (SWDs), particularly in the frontoparietal cortical region. In WAG/Rij and GAERS rats with absence epilepsy, recent evidence indicates that SWDs arise first from the lateral somatosensory cortex (LSC), that is, the

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