推薦產品
生物源
mouse
品質等級
重組細胞
expressed in NSO cells
無菌
sterile; sterile-filtered
化驗
>90% (SDS-PAGE)
形狀
lyophilized powder
分子量
monomer calculated mol wt 88.2 kDa
~120 kDa by SDS-PAGE (reducing)
calculated mol wt 88.2 kDa
包裝
pkg of 50 μg
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
運輸包裝
ambient
儲存溫度
−20°C
基因資訊
mouse ... Cdh1(12550)
相關類別
一般說明
E (epithelial)-cadherin is a type I classical cadherin, which exists as a dimer. It has an ectodomain made of five extracellular cadherin-like (EC) domains, connected by conserved linker regions, which are calcium-binding in nature. It spans the membrane once, and contains a cytoplasmic region.[1] It is a glycoprotein, and in humans has a molecular weight of 120kDa. It binds to catenin and cytoskeletal protein with its C-terminal domain.[2]
Extracellular domain of mouse E-Cadherin (amino acids 1-709) fused to the carboxy-terminal 6X histidine tagged Fc region of human IgG1.
應用
E-Cadherin/Fc Chimera from mouse has been used in adhesion assays.[3]
生化／生理作用
E (epithelial)-cadherin is involved in hemophilic cell-cell adhesion in a calcium-dependent manner. It forms adheren junctions through its ectodomains, to maintain physical contacts between adjacent cells.[1] It plays essential roles in developmental processes, tissue homeostasis and multiple diseases. In humans, this protein might be involved in the pathophysiology of ulcerative colitis. In Crohn′s diseased patients, mutations in this gene lead to a truncated or mislocalized protein product.[4] Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are the underlying processes of tumorigenesis and embryogenesis, and these involve the control of E-cadherin expression.[5]
外觀
Lyophilized from 0.2 μm filtered solution in 20mM MES, 300mM NaCl, 1mM CaCl2.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Xenopus δ-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases.
Gu D, et al.
Journal of Cell Science, 122(22), 4049-4061 (2009)
Dongmin Gu et al.
Journal of cell science, 122(Pt 22), 4049-4061 (2009-10-22)
Catenins of the p120 subclass display an array of intracellular localizations and functions. Although the genetic knockout of mouse delta-catenin results in mild cognitive dysfunction, we found severe effects of its depletion in Xenopus. delta-catenin in Xenopus is transcribed as
Ying Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(41), 16462-16467 (2013-09-27)
Epithelial cadherin (E-cadherin), a member of the classical cadherin family, mediates calcium-dependent homophilic cell-cell adhesion. Crystal structures of classical cadherins reveal an adhesive dimer interface featuring reciprocal exchange of N-terminal β-strands between two protomers. Previous work has identified a putative
Jessica I Grill et al.
Digestive diseases and sciences, 60(4), 895-902 (2015-01-31)
E-cadherin is a cell adhesion protein with crucial roles in development, tissue homeostasis, and disease. Loss of E-cadherin in the adult intestinal epithelium disrupts tissue architecture and is associated with impaired localization and function of goblet and Paneth cells, reduced
M J Bussemakers et al.
Molecular biology reports, 17(2), 123-128 (1993-02-01)
E-cadherin is a Ca(2+)-dependent cell adhesion molecule involved in cell-cell interaction. In its normal physiological function it plays an important role in embryonic development and tissue morphogenesis. Recent studies have shown that in cancer development E-cadherin can act as a
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