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E1406

Sigma-Aldrich

恩贝酸

≥98% (HPLC), powder

同義詞:

2,5-二羟基-3-十一烷基-2,5-环己二烯-1,4-二酮, 恩贝灵, 恩贝酸

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About This Item

經驗公式（希爾表示法）:
C17H26O4
CAS號碼:
550-24-3
分子量：:
294.39
EC號碼:
208-979-8
MDL號碼:
MFCD00016369
分類程式碼代碼:
12352200
PubChem物質ID:
24724473
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

溶解度

DMSO: >10 mg/mL
H2O: insoluble

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
parasites

作用方式

DNA synthesis | interferes

SMILES 字串

CCCCCCCCCCCC1=C(O)C(=O)C=C(O)C1=O

InChI

1S/C17H26O4/c1-2-3-4-5-6-7-8-9-10-11-13-16(20)14(18)12-15(19)17(13)21/h12,18,21H,2-11H2,1H3

InChI 密鑰

IRSFLDGTOHBADP-UHFFFAOYSA-N

基因資訊

human ... XIAP(331)

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一般說明

恩贝酸是一种天然的苯醌衍生物，最早从白花酸滕果植物中提取。它在结构上类似于泛醌。

應用

使用恩贝酸：
  • 研究其对活化T细胞(NFATc1)荧光素酶活性的核因子kB配体(RANKL)诱导的核因子的受体激活剂的影响
  • 研究其在介导帕金森病(PD)机制中的作用′
  • 治疗全鼠胚胎，以确定其对X连锁抑制细胞凋亡蛋白(XIAP)活性的影响

生化／生理作用

恩贝酸具有抗氧化、线粒体解耦联和抗生育特性。它还具有抗糖尿病、抗惊厥、抗焦虑和抗微生物活性等作用。恩贝酸是一种有效的神经保护剂，也可作为脑卒中的辅助治疗。
恩贝酸（Embelin）是XIAP（X连锁凋亡抑制蛋白）的抑制剂；体内抗肿瘤和抗炎活性。

象形圖

Health hazard
GHS08

訊號詞

Warning

危險聲明

H361f

防範說明

P201 - P308 + P313

危險分類

Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Uday P Kundap et al.
Frontiers in pharmacology, 8, 76-76 (2017-03-16)
A Central nervous system (CNS) disease is the one which affects either the spinal cord or brain and causing neurological or psychiatric complications. During the nineteenth century, modern medicines have occupied the therapy for many ailments and are widely used
Feng Li et al.
Biomacromolecules, 11(10), 2610-2620 (2010-09-02)
The objective of this study was to design lipopolymers for hydrophobic drug delivery. Poly(ethylene glycol)-block-poly(2-methyl-2-carboxyl-propylene carbonate-graft-dodecanol) (PEG-PCD) lipopolymers were synthesized and characterized by (1)H NMR, FT-IR, GPC, and DSC. The critical micelle concentration (CMC) of PEG-PCD micelles was around 10(-8)
Yixian Huang et al.
Bioconjugate chemistry, 23(7), 1443-1451 (2012-06-12)
Embelin, identified primarily from the Embelia ribes plant, has been shown to be a natural small molecule inhibitor of X-linked inhibitor of apoptosis protein (XIAP). It is also a potent inhibitor of NF-κB activation, which makes it a potentially effective
Boreddy Shivanandappa Thippeswamy et al.
European journal of pharmacology, 654(1), 100-105 (2010-12-28)
The aim of the present study is to evaluate the effect of embelin isolated from Embelia ribes on acetic acid induced colitis in rats. Experimental animals received embelin (25 and 50 mg/kg, p.o.) and sulfasalazine (100mg/kg, p.o.) for five consecutive
Zhonghui Lin et al.
Chemistry & biology, 20(2), 253-261 (2013-02-27)
Plasminogen activator inhibitor-1 (PAI-1), a serpin, is the physiological inhibitor of tissue-type and urokinase-type plasminogen activators and thus also an inhibitor of fibrinolysis and tissue remodeling. It is a potential therapeutic target in many pathological conditions, including thrombosis and cancer.
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