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D9446

Sigma-Aldrich

L-DOPS

≥98% (HPLC)

同義詞:

L-苏-3,4-二羟基苯基丝氨酸, 屈西多巴

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About This Item

經驗公式（希爾表示法）:
C9H11NO5
CAS號碼:
23651-95-8
分子量：:
213.19
MDL號碼:
MFCD00799030
分類程式碼代碼:
12352200
PubChem物質ID:
329798902
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to tan

溶解度

DMSO: ≥3 mg/mL

儲存溫度

−20°C

SMILES 字串

N[C@@H]([C@H](O)c1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1

InChI 密鑰

QXWYKJLNLSIPIN-JGVFFNPUSA-N

基因資訊

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

一般說明

L-DOPS又名L-苏-3,4-二羟基苯基丝氨酸或屈昔多巴，是一种儿茶酚胺。L-DOPS具有多种临床优势并可用于治疗去甲肾上腺素缺乏症。[1]它可用于治疗神经源性直立性低血压并改善去甲肾上腺素水平。[2]L-DOPS介导淀粉样斑块的减少，并具有治疗淀粉样蛋白病理学的潜力。[3]

應用

L-DOPS已用于具有淀粉样蛋白病理学小鼠的临床试验研究。[3]

生化／生理作用

L-DOPS是体内去甲肾上腺素的一种前体。

特點和優勢

该化合物收录于《受体分类和信号转导》手册的多巴胺、去甲肾上腺素和肾上腺素代谢页面。想要浏览手册的其他页面， 请单击此处。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000422237
0000422235
0000422237
0000422235
0000414816

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David S Goldstein et al.
Journal of clinical pharmacology, 51(1), 66-74 (2010-03-12)
L-threo-3,4-dihydroxyphenylserine (L-DOPS), a norepinephrine (NE) prodrug, is investigational for orthostatic hypotension, which occurs commonly in Parkinson's disease. Adjunctive anti-parkinsonian drugs might interact with L-DOPS. We tested whether L-aromatic amino-acid decarboxylase inhibition by carbidopa (CAR) attenuates L-DOPS conversion to NE and
Christopher J Mathias
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 18 Suppl 1, 25-29 (2008-04-23)
Neurogenic orthostatic hypotension is a cardinal feature of generalised autonomic failure and commonly is the presenting sign in patients with primary autonomic failure. Orthostatic hypotension can result in considerable morbidity and even mortality and is a major management problem in
Courtney Holmes et al.
Clinical chemistry, 56(5), 832-838 (2010-03-09)
L-threo-3,4-dihydroxyphenylserine (L-DOPS, droxidopa) is a norepinephrine (NE) prodrug under development to treat orthostatic hypotension. 3,4-Dihydroxyphenylacetaldehyde (DOPAL), an endogenous catecholaldehyde produced by enzymatic oxidative deamination of dopamine, is toxic to catecholaminergic neurons. Based on the observation of increasing plasma DOPAL after
Hui-Jeong Gwon et al.
Biotechnology letters, 32(1), 143-149 (2009-09-18)
Diastereoselectivity-enhanced mutants of L: -threonine aldolase (L: -TA) for L: -threo-3,4-dihydroxyphenylserine (L: -threo-DOPS) synthesis were isolated by error-prone PCR followed by a high-throughput screening. The most improved mutant was achieved from the mutant T3-3mm2, showing a 4-fold increase over the
Reyhaneh Torkzadeh-Mahani et al.
Ultrasonics sonochemistry, 56, 183-192 (2019-05-19)
The present work deals with the preparation of NiO/Co3O4 nanocomposites in presence of ultrasonic irradiation, and its use in electrochemical determination of Parkinson's drugs. NiO/Co3O4 nanocomposites are prepared using ultrasound assisted method. The impact of ultrasonic irradiation power (0, 75
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多巴胺、去甲肾上腺素和肾上腺素的合成

多巴胺-β-羟化酶位于去甲肾上腺素神经元的胺存储囊泡内。多巴胺通过主动运输而从细胞质转运到囊泡中。由于该酶是一种含铜的蛋白质，因此其活性会被铜螯合剂，如二乙基二硫代氨基甲酸酯和FLA-63所抑制。对该酶的抑制可有效降低组织去甲肾上腺素的水平。

Dopamine, Norepinephrine and Ephinephrine Synthesis

Dopamine-β-hydroxylase is located inside amine storage vesicles of norepinephrine neurons. Dopamine is actively transported from the cytoplasm into the vesicles. As the enzyme is a copper containing protein, its activity can be inhibited by copper chelating agents, such as diethyldithiocarbamate and FLA-63. Inhibition of the enzyme effectively reduces tissue norepinephrine levels.

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