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D5446

Sigma-Aldrich

7,8-二羟基黄酮水合物

≥98% (HPLC)

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About This Item

經驗公式（希爾表示法）:
C15H10O4 · xH2O
CAS號碼:
38183-03-8
分子量：:
254.24 (anhydrous basis)
EC號碼:
253-812-4
MDL號碼:
MFCD00006836
分類程式碼代碼:
12352200
PubChem物質ID:
329798806
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥98% (HPLC)

形狀

solid

儲存條件

desiccated

溶解度

DMSO: 24 mg/mL

儲存溫度

room temp

SMILES 字串

Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3

InChI

1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChI 密鑰

COCYGNDCWFKTMF-UHFFFAOYSA-N

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應用

7,8-二羟基黄酮水合物已被用作小鼠中原肌球蛋白受体激酶（TrkB）激动剂[1][2]，并用于抑制TrkB以监控诱发性兴奋性突触后电流 (eEPSC) 。[3]

生化／生理作用

7,8-二羟基黄酮是一种选择性TrkB受体激动剂
7,8-二羟基黄酮是一种选择性酪氨酸激酶受体B（TrkB）受体激动剂。它表现出了脑源性神经营养因子（BDNF）的所有治疗效果，如保护神经元免于凋亡、抑制红藻氨酸诱导的毒性、减少中风中的梗塞体积以及在帕金森病动物模型中的神经保护—没有BDNF限制了其治疗潜力的较差药代动力学特征。
7,8-二羟基黄酮（7,8-DHF），可用于帮助识别和区分由TrkB激活介导的生理效应和细胞信号传导通路，例如那些涉及的神经保护、记忆、血管舒张和高血压。[4]7,8-二羟基黄酮会引发对东莨菪碱所致阿尔茨海默样病变的保护作用。[5]

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000142759
0000123649
0000123650
0000075667
0000075668

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Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem
Jang M, et al.
eLife, 8, e42156-e42156 (2019)
7, 8-dihydroxyflavone ameliorates scopolamine-induced Alzheimer-like pathologic dysfunction
Chen C, et al.
Rejuvenation Research, 17(3), 249-254 (2014)
Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation
Kang MS, et al.
The Journal of Experimental Medicine, 214(10), 2947-2966 (2017)
Xiaojuan Liu et al.
Molecules (Basel, Switzerland), 25(4) (2020-02-23)
O-methylation of flavonoids is an important modification reaction that occurs in plants. O-methylation contributes to the structural diversity of flavonoids, which have several biological and pharmacological functions. In this study, an O-methyltransferase gene (CrOMT2) was isolated from the fruit peel
Maria N Schultz et al.
Learning & memory (Cold Spring Harbor, N.Y.), 27(9), 346-354 (2020-08-21)
Angelman syndrome is a rare neurodevelopmental disorder caused by a mutation in the maternal allele of the gene Ube3a The primary symptoms of Angelman syndrome are severe cognitive deficits, impaired motor functions, and speech disabilities. Analogous phenotypes have been detected
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Questions

  1. What are the recommended storage conditions for D5446 after reconstitution?

    1 answer

    1. Although there is no datasheet available for product D5446, there is information available for a product sharing the same CAS number from a different division. Below is the information found for product 506300 (7,8 Dihydroxyflavone):

      - Solubility: DMSO (100 mg/ml)
      - Storage: Protect from light, +2°C to +8°C
      - Do Not Freeze: Ok to freeze
      - Special Instructions: Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

      This information will also apply for product D5446. There are additional notes stating the product is packaged under inert gas. Therefore, if storing, it would be best to leave no air space in the storage container if possible. If that is not possible, it would be best to store under either dry nitrogen or argon.

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