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465119

Sigma-Aldrich

黄芩素

98%

同義詞:

5,6,7-三羟基黄酮

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About This Item

經驗公式（希爾表示法）:
C15H10O5
CAS號碼:
491-67-8
分子量：:
270.24
Beilstein:
272683
MDL號碼:
MFCD00017459
分類程式碼代碼:
12352100
PubChem物質ID:
24870246
NACRES:
NA.22
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化驗

98%

形狀

solid

mp

256-271 °C (lit.)

官能基

ketone
phenyl

SMILES 字串

Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

InChI 密鑰

FXNFHKRTJBSTCS-UHFFFAOYSA-N

基因資訊

mouse ... Hexa(15211)
rat ... Alox15(81639) , Alox5(25290)

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相關類別

一般說明

黄芩素是黄酮类化合物，是黄嘌呤氧化酶抑制剂。[1]研究了黄芩素在人外周白细胞中的抗炎作用。[2]

應用

黄芩素曾用于研究脂氧合酶的体外定量抑制。[3]

生化／生理作用

尼泊尔和中日天然药中的黄酮类成分。[4][5] 黄芩素是黄芩的主要黄酮，可抑制花生四烯酸代谢的12-脂氧合酶（12-LOX）途径，该途径可抑制癌细胞增殖并诱导细胞凋亡。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number
MKCX1335
MKCR0734
0000195123
0000239789
MKCS3854

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文章

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. At what percentage of DMso baicalein and naringin will be dissolved?

    1 answer

    1. Baicalein and can be soluble in 20mg/ml DMSO. Naringin can be soluble in 10 mg/ml neat DMSO.

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