推薦產品
產品名稱
(±)-DOI 盐酸盐, ≥98% (HPLC), solid
品質等級
化驗
≥98% (HPLC)
形狀
solid
drug control
Home Office Schedule 1; regulated under CDSA - not available from Sigma-Aldrich Canada
顏色
white to off-white
溶解度
H2O: 10 mg/mL
ethanol: 2 mg/mL
SMILES 字串
NC(C)CC1=CC(OC)=C(I)C=C1OC.Cl
InChI
1S/C11H16INO2.ClH/c1-7(13)4-8-5-11(15-3)9(12)6-10(8)14-2;/h5-7H,4,13H2,1-3H3;1H
InChI 密鑰
QVFDMWGKHUFODK-UHFFFAOYSA-N
基因資訊
human ... HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
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生化/生理作用
(±)-DOI盐酸盐是一种强效和选择性的5-HT2血清素受体激动剂,可穿过血脑屏障,增加多巴胺的周转,用DOI治疗可对抗尼古丁诱导的运动和神经化学敏化的表达,但对尼古丁诱导的行为去抑制没有影响。它对DOI的反应提供了证据,证明这些受体在皮质中含量丰富,在海马和小脑中含量相对较低。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
從最近期的版本中選擇一個:
分析證明 (COA)
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1. The behavioral responses, as well as the biogenic amines and metabolite contents in discrete brain areas were determined in male rats subcutaneously treated with a 5-HT1A (8-OHDPAT) or 5-HT2A (DOI) agonist at doses (0.5-2 mg/kg) sufficient to produce the
Scientific reports, 10(1), 21675-21675 (2020-12-12)
5-HT2A, a G-protein coupled receptor, is widely expressed in the human body, including in the gastrointestinal tract, platelets and the nervous system. It mediates various functions, for e.g. learning, memory, mood regulation, platelet aggregation and vasoconstriction, but its involvement in
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