推薦產品
生物源
Salvia miltiorrhiza
化驗
≥98% (HPLC)
形狀
powder
儲存條件
protect from light
顏色
red
溶解度
ethanol: 1 mg/mL, clear, orange to red
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
2-8°C
SMILES 字串
C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O
InChI
1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
InChI 密鑰
HARGZZNYNSYSGJ-JTQLQIEISA-N
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一般說明
DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.
應用
Dihydrotanshinone I (DHTS) has been used:
- to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
- as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
- as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor
- as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
- as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)
生化／生理作用
Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
分析證明 (COA)
Lot/Batch Number
15,16-Dihydrotanshinone I, a Compound of Salvia miltiorrhiza Bunge, Induces Apoptosis through Inducing Endoplasmic Reticular Stress in Human Prostate Carcinoma Cells.
Chuang MT, Ho FM, Wu CC, Zhuang SY, Lin SY, Suk FM, Liang YC.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2011 (2011)
Daifei Wang et al.
Biopharmaceutics & drug disposition, 41(1-2), 54-63 (2020-01-17)
Salvia miltiorrhiza is one of the most commonly used traditional Chinese medicines in the treatment of cardiovascular and cerebrovascular diseases. Cryptotanshinone (CTS), tanshinone IIA (Tan IIA), dihydrotanshinone I (diTan I), and tanshinone I (Tan I) are the main active compounds
Jing Chen et al.
Journal of immunology (Baltimore, Md. : 1950), 204(8), 2076-2087 (2020-03-15)
Dysregulated Th17 cell differentiation is associated with autoimmune diseases such as multiple sclerosis, which has no curative treatment. Understanding the molecular mechanisms of regulating Th17 cell differentiation will help find a novel therapeutic target for treating Th17 cell-mediated diseases. In
Preet Lal et al.
Nucleic acids research, 45(16), 9514-9527 (2017-09-22)
The Human antigen R protein (HuR) is an RNA-binding protein that recognizes U/AU-rich elements in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regulates the fate of target RNAs. The natural product dihydrotanshinone-I (DHTS) prevents the association
Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-targeted pathways.
Liu Q, Zhang Y, Lin Z, Shen H, Chen L, Hu L, Jiang H, Shen X.
The Journal of Steroid Biochemistry and Molecular Biology, 4-5, 155-163 (2010)
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