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Merck
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文件

C7397

Sigma-Aldrich

环磷酰胺 一水合物

ISOPAC®

同義詞:

2-[双(2-氯乙基)氨基]四氢-2H-1,3,2-噁磷-2-氧化物, Cytoxan

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About This Item

經驗公式(希爾表示法):
C7H15Cl2N2O2P · H2O
CAS號碼:
分子量::
279.10
Beilstein:
4678992
EC號碼:
MDL號碼:
分類程式碼代碼:
51112507
PubChem物質ID:
NACRES:
NA.25

化驗

97.0-103.0% (HPLC)

形狀

powder

mp

49-51 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

InChI 密鑰

PWOQRKCAHTVFLB-UHFFFAOYSA-N

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應用

环磷酰胺是氮芥类烷化剂,被广泛用于抗肿瘤和抗免疫药物的作用机理研究。

生化/生理作用

环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。

包裝

包装在 100 mL 血清瓶中,具有硅/PTFE 隔膜和铝封。

注意

将相容溶剂直接注入小瓶中,可制备任何所需规格的溶液,无需暴露。

重構

将内容物溶于 100 mL 溶剂中,得到 1% 溶液。

法律資訊

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC

產品號碼
描述
訂價

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


分析證明 (COA)

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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

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