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重要文件

C2394

Sigma-Aldrich

5-胆甾烯-3β-醇-7-酮

≥90%

同義詞:

3β-羟基-5-胆甾烯-7-酮, 7-酮基胆固醇

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About This Item

經驗公式(希爾表示法):
C27H44O2
CAS號碼:
分子量::
400.64
MDL號碼:
分類程式碼代碼:
41141804
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

化驗

≥90%

形狀

powder

官能基

ketone

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

C[C@]12CC[C@@]([C@](CC[C@H](O)C3)(C)C3=CC4=O)([H])[C@]4([H])[C@]1([H])CC[C@]2([H])[C@]([H])(C)CCCC(C)C

InChI

1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h16-18,20-23,25,28H,6-15H2,1-5H3/t18-,20+,21-,22+,23+,25+,26+,27-/m1/s1

InChI 密鑰

YIKKMWSQVKJCOP-ABXCMAEBSA-N

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應用

5-胆甾烯-3β-在通过 GC-MS [1] [2] 和 HPLC 测定胆固醇衍生物时,使用了醇-7-酮作为标准品。[3]

生化/生理作用

5-胆甾烯-3β-醇-7-酮是一种胆固醇衍生物,可降低脂质双分子层的膜电位。据报道,它在导致血管细胞凋亡的动脉粥样硬化斑块中蓄积。[4]

準備報告

5-胆甾烯-3β-在 250 mg/5 mL 氯仿中,醇-7-酮得到澄清至轻微浑浊、无色至淡黄色溶液。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Rapid analysis of oxidized cholesterol derivatives by high-performance liquid chromatography combined with diode-array ultraviolet and evaporative laser light-scattering detection
Osada K et al
Journal of the American Oil Chemists' Society, 76, 863-871 (1999)
Thomas Starke-Peterkovic et al.
Biophysical journal, 90(11), 4060-4070 (2006-03-04)
The effect of cholesterol removal by methyl-beta-cyclodextrin on the dipole potential, psi(d), of membrane vesicles composed of natural membrane lipids extracted from the kidney and brain of eight vertebrate species was investigated using the voltage-sensitive fluorescent probe di-8-ANEPPS. Cyclodextrin treatment
E Boselli et al.
Journal of chromatography. A, 917(1-2), 239-244 (2001-06-14)
Pressurized liquid extraction (PLE, ASE) was compared with the Folch procedure (a solid-liquid extraction with chloroform/methanol 2:1, v/v) for the lipid extraction of egg-containing food; the accuracy of PLE for the quantitative determination of oxysterols in whole egg powder was
C Adcox et al.
Journal of agricultural and food chemistry, 49(4), 2090-2095 (2001-04-20)
The cytotoxicity of cholesterol and a mixture of beta-sitosterol/campesterol (50%/40%) and their oxides was examined in a cultured-derived macrophage cell line, C57BL/6. Cell numbers, lactate dehydrogenase (LDH) leakage, protein content, lipid uptake, and mitochondria dehydrogenase activity were determined after exposure
Anne Pilotelle-Bunner et al.
Biochimica et biophysica acta, 1787(8), 1039-1049 (2009-03-25)
Three different cholesterol derivatives and phloretin, known to affect the local electric field in phospholipid membranes, have been introduced into Rhodobacter sphaeroides reaction centre-containing phospholipid liposomes. We show that cholesterol and 6-ketocholestanol significantly slow down the interquinone first electron transfer

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