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About This Item
經驗公式（希爾表示法）:
C22H30O4
CAS號碼:
分子量：:
358.47
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.79
暫時無法取得訂價和供貨情況
推薦產品
品質等級
化驗
≥98%
形狀
powder
技術
HPLC: suitable
顏色
white to off-white
儲存溫度
2-8°C
SMILES 字串
CC(=O)OCC1(O)CC23CCC4c5ccoc5CCC4(C)C2CCC1C3
InChI
1S/C22H30O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h7,10,15,17,19,24H,3-6,8-9,11-13H2,1-2H3
InChI 密鑰
PTGGVIKFNQSFBY-UHFFFAOYSA-N
應用
Cafestol acetate has been used to determine the effects of coffee on heat shock response (HSR).[1]
生化／生理作用
Cafestol is a coffee-specific diterpene.[2] It has anti-carcinogenic and anti-inflammatory activities.[3] Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage.[2] Cafestol increases the level of glutathione (GSH), by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450.[3]
其他說明
Furan-containing diterpene from green coffee beans.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Coffee extract and caffeine enhance the heat shock response and promote proteostasis in an HSF-1-dependent manner in Caenorhabditis elegans
Brunquell J, et al.
Cell Stress & Chaperones, 23(1), 65-75 (2018)
Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer
Gaascht F, et al.
Genes & Nutrition, 10(6), 51-51 (2015)
Pablo Muriel et al.
Fitoterapia, 81(5), 297-305 (2009-10-15)
Coffee consumption is worldwide spread with few side effects. Interestingly, coffee intake has been inversely related to the serum enzyme activities gamma-glutamyltransferase, and alanine aminotransferase in studies performed in various countries. In addition, epidemiological results, taken together, indicate that coffee
Ting Shen et al.
Biological & pharmaceutical bulletin, 33(1), 128-132 (2010-01-05)
Coffee is a popular beverage worldwide with various nutritional benefits. Diterpene cafestol, one of the major components of coffee, contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects. In this study
Kyung Jin Lee et al.
Toxicology letters, 173(2), 80-87 (2007-08-11)
There is an increasing evidence that oxidative stress is implicated in the processes of inflammation and carcinogenesis. It has been shown that kahweol and cafestol, coffee-specific diterpenes, exhibit chemoprotective effects. This study investigated the effects of kahweol and cafestol, coffee-specific
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