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重要文件

C0158

Sigma-Aldrich

L -肉碱 内盐

≥98%

同義詞:

左旋肉毒碱, 维生素 BT

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About This Item

線性公式:
(CH3)3N+CH2CH(OH)CH2COO-
CAS號碼:
分子量::
161.20
Beilstein:
4292315
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.79
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產品名稱

L -肉碱 内盐, synthetic, ≥98%

生物源

synthetic

品質等級

化驗

≥98%

形狀

powder

顏色

white

mp

197-212 °C (lit.)

應用

cell analysis
detection

SMILES 字串

C[N+](C)(C)C[C@H](O)CC([O-])=O

InChI

1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1

InChI 密鑰

PHIQHXFUZVPYII-ZCFIWIBFSA-N

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應用

L-肉碱内盐已被用作Seahorse XF线粒体应激测定中的测定培养基的组分。[1]它还被口服给予荷瘤小鼠,以研究其对过氧化物酶体增殖物激活受体的调节作用,从而对肝脏炎症反应进行分析。[2]

生化/生理作用

肉碱由赖氨酸生物合成。肉碱可促进脂肪酸转运至线粒体区室中。[3]在骨骼肌和心肌组织中,它充当代谢辅助因子。肉碱可能与支链氨基酸的能量产生有关。[4]
肉毒碱是一种天然存在于大多数哺乳动物组织中的季铵。它在骨骼肌和心脏中参与能量代谢调控,浓度相对较高。它可将葡萄糖代谢由糖酵解转移至糖原储存,并促进长链脂肪酸向线粒体转运,使其在线粒体氧化产生能量。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Sunil K Panchal et al.
Food & function, 6(8), 2496-2506 (2015-07-21)
Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular
Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles
Rui Li
The Journal of Physiology, 594(24), 7197-7213 (2016)
N A Oey et al.
Placenta, 27(8), 841-846 (2005-11-23)
Carnitine plays an indispensable role in fatty acid oxidation. Previous studies revealed that fetal carnitine is derived from the mother via transplacental transfer. Recent studies demonstrated the presence and importance of an active fatty acid oxidation system in the human
L-carnitine ameliorates the liver inflammatory response by regulating carnitine palmitoyltransferase I-dependent PPAR? signaling
Fang Jiang
Molecular Medicine Reports, 13(2) (2015)
Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.
Koeth RA
Nature Medicine, 19(5), 576-585 (2013)

Questions

  1. Hello, After dissolving the product in water, I want to ask about the storage conditions to ensure the stability of the product L-carnitine inner salt, product number C0158.

    1 answer
    1. The solution stability of this product has not been determined. It is recommended to prepare solutions fresh before use.

      Helpful?

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