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重要文件

B7283

Sigma-Aldrich

多巴丝肼 盐酸盐

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

同義詞:

DL -丝氨酸 2-(2,3,4-三羟基苄基)酰肼 盐酸盐

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About This Item

經驗公式(希爾表示法):
C10H15N3O5 · HCl
CAS號碼:
分子量::
293.70
EC號碼:
MDL號碼:
分類程式碼代碼:
12352125
PubChem物質ID:
NACRES:
NA.77
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產品名稱

多巴丝肼 盐酸盐, ≥98% (HPLC), solid

生物源

synthetic

化驗

≥98% (HPLC)

形狀

solid

溶解度

H2O: 10 mg/mL

起源

Roche

儲存溫度

room temp

SMILES 字串

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI 密鑰

ULFCBIUXQQYDEI-UHFFFAOYSA-N

基因資訊

human ... DDC(1644)

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一般說明

苄丝肼是一种外周脱羧酶抑制剂。[1]

應用

使用苄丝肼:
  • 抑制多巴脱羧酶[2]
  • 诱导运动障碍[3]
  • 测试纯化细菌TDC,以评估其对细菌脱羧酶的影响程度[4]
  • 作为外周多巴脱羧酶抑制剂治疗小鼠[5]

生化/生理作用

L -芳香族氨基酸脱羧酶抑制剂。
苄丝肼能够在体外阻断HK2酶活性。可与左旋多巴一同使用治疗帕金森氏症′。 [6]

特點和優勢

该化合物由 Roche 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

Lot/Batch Number

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Waller DG, et al.
Medical Microbiology, 325-336 (2018)
Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo
Goltsev Y, et al.
Developmental Biology, 330(2), 462-470 (2009)
Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson?s disease
van KSP, et al.
Nature Communications, 10(1), 310-310 (2019)
Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
Tillerson JL, et al.
Experimental Neurology, 178, 80-90 (2002)

文章

血清素儲存在細胞中,並經 MAO 代謝,影響中樞神經系統、消化道和血小板功能。

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

DISCOVER Bioactive Small Molecules for Neuroscience

Questions

  1. What is the recommended storage temperature for Benserazide hydrochloride (Product B7283) after the drug is suspended in water?

    1 answer
    1. Benserazide hydrochloride is soluble in water and should be dissolved in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. The solutions decompose on exposure to light and air. Benserazide HCl is a tan, photosensitive solid and should be stored tightly sealed at -4°C, protected from exposure to light. It is not recommended to store the aqueous solution for more than one day.

      Additionally, the product is subject to oxidation, and it is advisable to make solutions fresh daily. The product should be stored, as supplied, at room temperature for up to 1 year, and it should be protected from light.

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