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About This Item
經驗公式（希爾表示法）:
C9H4N4O4S
CAS號碼:
分子量：:
264.22
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
tan
溶解度
H2O: <2 mL/mL
DMSO: ≥5 mg/mL
儲存溫度
2-8°C
SMILES 字串
NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O
InChI
1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14)
InChI 密鑰
FKRBAXZAJBBIAJ-UHFFFAOYSA-N
生化／生理作用
BTO-1 is a polo-like kinase (Plk) inhibitor.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Campbell McInnes et al.
Nature chemical biology, 2(11), 608-617 (2006-10-10)
Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and for developing antitumor agents. Guided by homology modeling of the Plk1
Mark E Burkard et al.
PLoS biology, 7(5), e1000111-e1000111 (2009-05-27)
Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle
Keiko Yata et al.
Molecular cell, 45(3), 371-383 (2012-02-14)
Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1)
Kristin P Leister et al.
Current chemical genomics, 5, 21-29 (2011-06-07)
Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for detecting TNF-α, enzyme linked immunosorbent assay (ELISA) and radioimmunoassay, are not
Conrad von Schubert et al.
PLoS biology, 8(9) (2010-10-12)
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium that resides free in the host
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