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Merck
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Key Documents

AV36668

Sigma-Aldrich

Anti-MCM8 antibody produced in rabbit

affinity isolated antibody

同義詞:

Anti-C20orf154, Anti-MGC119522, Anti-MGC119523, Anti-MGC12866, Anti-MGC4816, Anti-Minichromosome maintenance complex component 8, Anti-REC, Anti-dJ967N21.5

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

94 kDa

物種活性

bovine, rabbit, human, guinea pig, horse, rat, mouse

濃度

0.5 mg - 1 mg/mL

技術

immunohistochemistry: suitable
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... MCM8(84515)

相關類別

免疫原

Synthetic peptide directed towards the C terminal region of human MCM8

生化/生理作用

Minichromosome maintenance complex component 8 (MCM8) is one of the mini-chromosome maintenance proteins that are crucial for eukaryotic genome replication. MCM proteins are key components of the pre-replication complex, recruit replication-related proteins and form replication forks. MCM8 complexes with MCM9 to recruit RAD51 at the sites of DNA damage to facilitate homologous recombination.

序列

Synthetic peptide located within the following region: IRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQH

外觀

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Jonghoon Park et al.
Molecular and cellular biology, 33(8), 1632-1644 (2013-02-13)
The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication elongation and prereplication complex (pre-RC) formation, respectively. We found that MCM8 and MCM9 physically associate with each other and that MCM8 is required for the
The dimeric Mcm8-9 complex of Xenopus laevis likely has a conserved function for resistance to DNA damage.
Masato T Kanemaki
Cell cycle (Georgetown, Tex.), 12(9), 1338-1339 (2013-04-17)
Matthew L Bochman et al.
Microbiology and molecular biology reviews : MMBR, 73(4), 652-683 (2009-12-01)
The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork progression during DNA replication. Consistent with its central role in this process, much prior work has illustrated that Mcm2-7 loading

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