推薦產品
生物源
rabbit
品質等級
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~70 kDa
物種活性
chicken, rat, canine, human, monkey, mouse, bovine
技術
immunoblotting: 1:250-1:500 using different cell extracts
immunoprecipitation (IP): 10-20 μg/test
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HSPA1A(3303)
一般說明
Heat Shock Proteins 70 (HSP70), also known as HSPA1A (heat shock protein family A (Hsp70) member 1A) or HSPA1B (heat shock protein family A (Hsp70) member 1B) is encoded by the gene mapped to human chromosome 6p21.3. xHSP70 is a highly conserved protein family with four members such as the constitutive (or cognate) HSP73, the stress-inducible HSP72, the glucose regulated proteins (grp)78 and grp75. During heat shock, HSP70s concentrate in the cell nuclei and return to the cytoplasm when the shock is removed.
免疫原
Synthetic peptide from the internal region of human HSP70 protein, conjugated to KLH
應用
The antibody has been used in various immunochemical techniques including immunoblotting (∼70 kDa) and immunoprecipitation.Detection of the HSP70 band by Immunoblotting is specifically inhibited by the immunogen.
生化／生理作用
Heat Shock Proteins 70 (HSP70) plays a key role in stress response, including heat stress, in every organism in which the proteins have been examined. These proteins also facilitates a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. In addition, HSP70 also play a cytoprotective role in neurodegenerative diseases such as Alzheimer′s, Parkinson′s, Huntington′s, ALS and others. Unregulated expression of HSP70s leads to the development of several types of cancer, such as malignant melanoma and renal cell cancer.
外觀
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
其他說明
This product is for R&D use only, not for drug, household, or other uses.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Georgios D Lianos et al.
Cancer letters, 360(2), 114-118 (2015-02-28)
Heat shock proteins (HSPs) are an evolutionary family of proteins that act as molecular chaperones. According to their size they have been classified into the following families; HSP90, HSP70, HSP60, HSP40 and HSP27. They prevent the formation of nonspecific protein
M Tavaria et al.
Cell stress & chaperones, 1(1), 23-28 (1996-04-01)
The human Hsp70 family encompasses at least 11 genes which encode a group of highly related proteins. These proteins include both cognate and highly inducible members, at least some of which act as molecular chaperones. The location of cognate Hsp70s
Hsp70 dynamics in vivo: effect of heat shock and protein aggregation
Zeng X, et al.
Journal of Cell Science, 117(21), 4991-5000 (2004)
Heat shock protein 70 in Alzheimer?s disease
Lu RC, et al.
BioMed Research International, 2014(21) (2014)
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