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A7015

Sigma-Aldrich

N-(2-芴基)乙酰胺

≥98% (HPLC)

同義詞:

2-AAF, 2-乙酰氨基芴, N-乙酰基-2-氨基芴

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About This Item

經驗公式（希爾表示法）:
C15H13NO
CAS號碼:
53-96-3
分子量：:
223.27
Beilstein:
2807677
EC號碼:
200-188-6
MDL號碼:
MFCD00001116
分類程式碼代碼:
12352103
PubChem物質ID:
24891166
NACRES:
NA.25

化驗

≥98% (HPLC)

形狀

powder

mp

192-196 °C (lit.)

SMILES 字串

CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1

InChI

1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)

InChI 密鑰

CZIHNRWJTSTCEX-UHFFFAOYSA-N

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應用

N-（2-氟烯基）乙酰胺（2-乙酰氨基芴，2-AAF）是一种用于在2-AAF/部分肝切除大鼠等动物模型中诱发肝癌的遗传毒性致癌物。2-AAF可用于研究肝癌发生的机制，并在其鉴定或定量过程中用作参考材料。

生化／生理作用

一种遗传毒性致癌物，用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时，2-AAF 与 DNA 形成加合物，在肝脏和膀胱中发生肿瘤。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險聲明

H302,H350

危險分類

Acute Tox. 4 Oral - Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SLCD1839
SLBS9794
SLBT5494
SLBT5333
SLBS9801

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Bu-Gao Zhou et al.
Frontiers in pharmacology, 9, 1165-1165 (2018-11-09)
It is known that excessive hepatocellular apoptosis is a typical characteristic of hepatic disease, and is regulated by the mammalian target of rapamycin (mTOR) signaling pathway. As the main active component of Kudzu (Pueraria lobata) roots, which is frequently used
Sana Javaid Awan et al.
Cell biology international, 41(1), 51-61 (2016-11-03)
Hepatic oval cells are likely to be activated during advanced stage of liver fibrosis to reconstruct damaged hepatic tissue. However, their scarcity, difficulties in isolation, and in vitro expansion hampered their transplantation in fibrotic liver. This study was aimed to
Hong Mu et al.
Nucleic acids research, 40(19), 9675-9690 (2012-08-21)
Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2'-deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) and N-(2'-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) adducts that differ by a single acetyl group. The NER
Jung-Eun Yeo et al.
Chemical research in toxicology, 25(11), 2462-2468 (2012-10-24)
Nucleotide excision repair (NER) removes lesions caused by environmental mutagens or UV light from DNA. A hallmark of NER is the extraordinarily wide substrate specificity, raising the question of how one set of proteins is able to recognize structurally diverse
Samrat Chakraborty et al.
Molecular therapy. Nucleic acids, 20, 34-49 (2020-03-09)
Site-specific delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes should be a focus for potential therapeutic management of hepatocellular carcinoma (HCC). The aptamer TLS 9a with phosphorothioate backbone modifications (L5) has not been explored so far for
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