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Merck
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重要文件

A7015

Sigma-Aldrich

N-(2-芴基)乙酰胺

≥98% (HPLC)

同義詞:

2-AAF, 2-乙酰氨基芴, N-乙酰基-2-氨基芴

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About This Item

經驗公式(希爾表示法):
C15H13NO
CAS號碼:
分子量::
223.27
Beilstein:
2807677
EC號碼:
MDL號碼:
分類程式碼代碼:
12352103
PubChem物質ID:
NACRES:
NA.25

化驗

≥98% (HPLC)

形狀

powder

mp

192-196 °C (lit.)

SMILES 字串

CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1

InChI

1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)

InChI 密鑰

CZIHNRWJTSTCEX-UHFFFAOYSA-N

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應用

N-(2-氟烯基)乙酰胺(2-乙酰氨基芴,2-AAF)是一种用于在2-AAF/部分肝切除大鼠等动物模型中诱发肝癌的遗传毒性致癌物。2-AAF可用于研究肝癌发生的机制,并在其鉴定或定量过程中用作参考材料。

生化/生理作用

一种遗传毒性致癌物,用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时,2-AAF 与 DNA 形成加合物,在肝脏和膀胱中发生肿瘤。

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Oral - Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges


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