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A3913

Sigma-Aldrich

L-Argininamide dihydrochloride

≥98%, suitable for ligand binding assays

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About This Item

經驗公式（希爾表示法）:
C6H15N5O · 2HCl
CAS號碼:
14975-30-5
分子量：:
246.14
MDL號碼:
MFCD00058286
分類程式碼代碼:
12352209
PubChem物質ID:
24890827
NACRES:
NA.26
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產品名稱

L-Argininamide dihydrochloride,

化驗

≥98%

品質等級

200

形狀

powder

技術

ligand binding assay: suitable

顏色

white to off-white

儲存溫度

−20°C

SMILES 字串

Cl.N[C@@H](CCCNC(N)=N)C(N)=O

InChI

1S/C6H15N5O.ClH/c7-4(5(8)12)2-1-3-11-6(9)10;/h4H,1-3,7H2,(H2,8,12)(H4,9,10,11);1H/t4-;/m0./s1

InChI 密鑰

BPQLYFCEVVKLLX-WCCKRBBISA-N

相關類別

應用

L-Argininamide dihydrochloride has been used as an additive to compare its effect over L-arg in egg lysozyme refolding studies.[1] It has also been used as a component of substrate stock solution for enzymatic kyotorphin synthesis.[2]

生化／生理作用

L-Argininamide (L-Arm) is a hydrophilic amino acid derivative[2] that is used as a model compound in physicochemical characteristic studies of ligand binding DNA aptamers and their potential development as fluorescent aptasensors.[3]

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險聲明

H302,H370

危險分類

Acute Tox. 4 Oral - STOT SE 1

標靶器官

Eyes

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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分析證明 (COA)

Lot/Batch Number
BCCK8934
BCCF9587
BCBV9948
BCBQ1412V
BCBQ1412

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G Reid Bishop et al.
Biophysical chemistry, 126(1-3), 165-175 (2006-08-18)
The thermal stability and ligand binding properties of the L-argininamide-binding DNA aptamer (5'-GATCGAAACGTAGCGCCTTCGATC-3') were studied by spectroscopic and calorimetric methods. Differential calorimetric studies showed that the uncomplexed aptamer melted in a two-state reaction with a melting temperature T(m)=50.2+/-0.2 degrees C
Max Keller et al.
Bioorganic & medicinal chemistry, 19(9), 2859-2878 (2011-04-16)
Fluorescently labelled NPY Y(1) receptor (Y(1)R) ligands were synthesized by connecting pyrylium and cyanine dyes with the argininamide-type Y(1)R antagonist core structure by linkers, covering a wide variety in length and chemical nature, attached to the guanidine group. The most
Zhiai Xu et al.
Biosensors & bioelectronics, 26(12), 4733-4738 (2011-07-02)
Aptamers are nucleic acids that can selectively bind to a variety of targets. Aptamers usually undergo conformational transitions from a flexible or disordered structure into a rigid or ordered structure upon target-binding. This study describes a detection method for l-argininamide
Tao Li et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 13(23), 6718-6723 (2007-05-17)
We report a novel label-free method for the investigation of the adaptive recognition of small molecules by nucleic acid aptamers using capillary electrophoresis analysis. Cocaine and argininamide were chosen as model molecules, and the two corresponding DNA aptamers were used.
Zece Zhu et al.
Chemical communications (Cambridge, England), 47(11), 3192-3194 (2011-01-29)
The nucleic acid minor groove binding dyes, DAPI and Hoechst 33258, were for the first time used in label-free aptamer-based sensors for L-argininamide. The synergy binding effect results in the enhancement of fluorescence of dyes. The method for detection of
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