跳轉至內容
Merck
全部照片(1)

重要文件

檢視所有文件

A2900

Sigma-Aldrich

[Val5]-血管紧张素II 乙酸盐 水合物

≥95% (HPLC), powder

同義詞:

Angiotensin II Acetate

登入查看組織和合約定價
全部照片(1)

About This Item

經驗公式（希爾表示法）:
C49H69N13O12 · xC2H4O2 · yH2O
分子量：:
1032.15 (anhydrous free base basis)
分類程式碼代碼:
12352209
PubChem物質ID:
329770803
NACRES:
NA.77
暫時無法取得訂價和供貨情況

品質等級

200

化驗

≥95% (HPLC)

形狀

powder

成份

acetate, 1.2-10.4%

儲存溫度

−20°C

SMILES 字串

O.CC(O)=O.CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(O)=O

InChI

1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4;/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4);1H2/t32-,33-,34-,35-,36-,37-,39-,40-;;/m0../s1

InChI 密鑰

INQPQDZJLFYCRH-AXOAQIBVSA-N

基因資訊

human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180)

尋找類似的產品？ 前往 產品比較指南

Amino Acid Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe

一般說明

[Val5]-血管紧张素II（[Val5]-ANG Ii）是一种含ANG II模拟物，在ANG II八肽中含有缬氨酸作为第5个氨基酸取代异亮氨酸。[1]

應用

[Val5]-血管紧张素II醋酸盐水合物已用于诱导：
  • 小鼠肾脏损伤，以研究人肝型脂肪酸结合蛋白（hL-FABP）的作用[1]
  • 小鼠血管炎症，以研究胞质铜伴侣抗氧化剂-1（Atox1）与肿瘤坏死因子（TNF）受体相关因子4（TRAF4）之间的相互作用[2]
  • 小鼠腹主动脉瘤（AAA），以研究血管ATP酶铜转运α（ATP7α）的作用[3]

生化／生理作用

[Val5]-血管紧张素II可用作血管紧张素II 1型受体（AT1受体）的激动剂。[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
0000441480
0000441480
0000370151
0000310201
0000344572

未看到正確版本？

如果您需要一個特定的版本，您可以透過批號來尋找特定憑證。

搜尋 COA

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

客戶也查看了

Slide 1 of 1

1 of 1

氯沙坦钾

Supelco

61188

氯沙坦钾

Archita Das et al.
American journal of physiology. Cell physiology, 317(6), C1161-C1171 (2019-09-26)
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases. We reported that in proinflammatory cytokine TNF-α-stimulated endothelial cells (ECs), cytosolic Cu chaperone antioxidant-1 (Atox1) functions as a Cu-dependent transcription
Daisuke Ichikawa et al.
Hypertension (Dallas, Tex. : 1979), 60(4), 973-980 (2012-08-29)
To investigate the role of human liver-type fatty acid binding protein (hL-FABP) in angiotensin (Ang) II-induced renal injury, Ang II was infused systemically into hL-FABP chromosomal transgenic (Tg) and wild-type (WT) mice (Tg-Ang II and WT-Ang II) for 28 days.
D G Butler et al.
Archives internationales de pharmacodynamie et de therapie, 329(2), 272-282 (1995-03-01)
Pressor responses to [Ile5]-Angiotensin II and [Val5]-Angiotensin II were measured following single intravenous doses of 0.0075, 0.075, 0.375, 0.75 and 7.5 micrograms/kg b.w. in anesthetised rats. [Val5]-Angiotensin II was significantly (10 per cent) more potent than [Ile5]-angiotensin II when log
L X Zou et al.
American journal of hypertension, 11(5), 570-578 (1998-06-20)
Previous studies have demonstrated that augmentation of intrarenal angiotensin II (ANG II) levels during ANG II induced hypertension involves both endogenous formation and accumulation of circulating ANG II. The present work extends these findings and determines whether accumulation of infused
Nicolas Pelisch et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 33(2), 161-164 (2009-11-28)
The renin-angiotensin system has an important function in the regulation of blood pressure as well as in pathophysiological processes in the central nervous system. We examined the effects of the angiotensin receptor blocker candesartan (10 mg kg(-1) per day, p.o.)
查看所有相關論文

Questions

Reviews

No rating value

Active Filters

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務