推薦產品
化驗
≥99% (TLC)
形狀
powder
mp
157-159 °C (lit.)
溶解度
water: 50 mg/mL, clear, colorless
儲存溫度
2-8°C
SMILES 字串
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2N=CC(=O)NC2=O
InChI
1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/m1/s1
InChI 密鑰
WYXSYVWAUAUWLD-SHUUEZRQSA-N
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一般說明
6-氮杂尿苷是嘧啶核苷类似物。
應用
6-氮杂尿苷已用于：
- 用于尿苷一磷酸合酶（UMPS）活性测定
- 作为抗病毒药物，研究其对足口病病毒的抑制效应和细胞毒活性
- 筛选抗隐孢子虫活性
- 对HeLa细胞进行预处理，以研究捕获5-溴尿苷5′-三磷酸（BrUTP）前和捕获过程中抑制细胞尿苷合成的效应
- 用作参照化合物，比较其对病毒宿主细胞株的抗病毒活性和细胞毒活性
6-氮杂尿苷（AzUrd）阻止乳清酸转化为UMP，并用于抗病毒研究。
生化／生理作用
6-氮杂尿苷是一种前药，在转化为6-氮杂-UMP后会抑制尿苷单磷酸合酶（UMPS）。它是一种广谱的抗代谢药。它干扰嘧啶的生物合成并影响细胞核酸水平。它被认为是一种抗肿瘤代谢物。它抑制基孔肯雅病毒、塞姆利基森林病毒和人类冠状病毒等RNA病毒。它显著抑制隐孢子虫寄生虫的生长。
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Carc. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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