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42867

Sigma-Aldrich

硫酸葡聚糖 钠盐

Mr ~40,000

同義詞:

DSS Dextran Sulfate Sodium

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About This Item

分類程式碼代碼:
12352201
NACRES:
NA.25
暫時無法取得訂價和供貨情況

形狀

powder

品質等級

分子量

Mr ~40,000

損耗

≤10% loss on drying

顏色

white to off-white

有用的pH值範圍

6.0-8 (10 g/L)

mp

(Decomposes on heating.)

溶解度

water: soluble

儲存溫度

room temp

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一般說明

右旋糖酐是一种无水葡萄糖的聚合物。 由大约95%的α-D-(166)键组成。 其它(163)链接组成了葡聚糖的支链。

應用

硫酸葡聚糖通常用于选择性沉淀脂蛋白,探针杂交膜固定DNA,从DNA-组蛋白复合物中释放DNA,以及抑制RNA与核糖体结合。

生化/生理作用

葡聚糖硫酸钠通过与结肠中链脂肪酸结合并诱导炎症,在小鼠和大鼠体内引发结肠炎。 [1]

其他說明

为了全面了解我们针对客户研究提供的各种葡聚糖产品,建议您访问我们的碳水化合物分类页面。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Andrey V Markov et al.
Molecules (Basel, Switzerland), 25(10) (2020-05-28)
Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid derivative soloxolone methyl
Hamed Laroui et al.
PloS one, 7(3), e32084-e32084 (2012-03-20)
Inflammatory bowel diseases (IBDs), primarily ulcerative colitis and Crohn's disease, are inflammatory disorders caused by multiple factors. Research on IBD has often used the dextran sodium sulfate (DSS)-induced colitis mouse model. DSS induces in vivo but not in vitro intestinal
Li Cao et al.
International immunopharmacology, 72, 264-274 (2019-04-21)
Extracellular vesicles (EVs) secreted by bone marrow mesenchymal stem cells (BMSCs) have shown repairing effects in tissue damage. However, their efficacy and mechanism in the treatment of ulcerative colitis (UC), a type of chronic inflammatory bowel disease, are unclear. To
N Facchinello et al.
Scientific reports, 7(1), 4371-4371 (2017-07-01)
Glucocorticoids (GCs) play important roles in developmental and physiological processes through the transcriptional activity of their cognate receptor (Gr). Using CRISPR/Cas9 technology, we established a zebrafish null Gr mutant line and compared its phenotypes with wild type and a zebrafish
Yueqin He et al.
Scientific reports, 10(1), 10180-10180 (2020-06-25)
CD47 deficient mice are resistant to dextran sulfate sodium (DSS)-induced experimental colitis. The underlying mechanism, however, remains incompletely understood. In this study, we characterized the role of CD47 in modulating homeostasis of gastrointestinal tract. We found that CD47 expression in

文章

Centrifugation enables the separation of particles by sedimentation. Learn how to separate particles using a centrifuge and how to use Stokes' law to calculate the velocity of sedimentation.

離心法可藉由沉降將微粒分離。學習如何使用離心機分離微粒,以及如何使用斯托克斯定律計算沉降速度。

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

探索 FITC 標示的多醣體及其特性,包括分子量對分子尺寸的影響。

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Does DDS (Dextran Sodium Sulfate) come in a USP grade for a animal studies?

    1 answer
    1. Unfortunately, there is no pharmaceutical grade Dextran Sodium Sulfate available at this time. This product is not tested for use in animal models. It would be up to the researcher to determine suitability.

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  4. Hello! I want to know if you can autoclave water with 4% of dextran sulfate sodium (DSS) without decomposing the DSS.

    1 answer
    1. The solubility of dextran sulfates is tested at 100 mg/mL in water. Clear solutions are obtained. Buffered aqueous dextran sulfate solutions can be sterilized by autoclaving at 110-115 °C for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. Dextran sulfate has a higher affinity for calcium ions than for sodium ions. The calcium salt of dextran sulfate is insoluble. The free acid (hydrogen) form of dextran sulfate is extremely acidic and autohydrolyzes rapidly in solution and as a powder.

      More information can be found here: https://www.sigmaaldrich.com/technical-documents/protocol/protein-biology/protein-pulldown/dextran-sulfate

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