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重要文件

30891

Sigma-Aldrich

胆绿素 盐酸盐

≥97.0% (TLC)

同義詞:

胆绿素

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About This Item

經驗公式(希爾表示法):
C33H34N4O6 · HCl
CAS號碼:
分子量::
619.11
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32
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化驗

≥97.0% (TLC)

形狀

powder or crystals

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

−20°C

SMILES 字串

Cl.CC1=C(C=C)C(\NC1=O)=C\c2[nH]c(/C=C3\N=C(\C=C4/NC(=O)C(C=C)=C4C)C(C)=C3CCC(O)=O)c(CCC(O)=O)c2C

InChI

1S/C33H34N4O6.ClH/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26;/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41);1H/b26-13-,27-14-,28-15-;

InChI 密鑰

KTRFJVRKVQROKS-UJCZHUFNSA-N

一般說明

胆绿素(BV)被认为是内源性近红外(NIR)吸收色素。[1] 它是血红素降解(血红素分解代谢)为胆红素的线性四吡咯中间体。[2][3]两栖类和鸟类的胆汁只含胆绿素,不含胆红素。

應用

胆绿素盐酸盐已:
  • 用于处理J774A.1细胞,以研究其在β (β)-内啡肽水平变化中的作用[4]
  • 作为商业标准品,使用气相色谱-质谱分析法(GC-MS)检测小鼠不稳定和稳定斑块组织中的胆绿素[5]
  • 添加含Fucci细胞以改进mIFP信号[6]
  • 在一些视网膜制剂中检测对红外荧光蛋白(iRFP)的影响[7]

生化/生理作用

胆绿素(BV)是一种优秀的抗炎剂,可抵御脂多糖(LPS)诱导的小鼠内皮细胞肺损伤。[8]它有助于保护多微生物败血症。[9]胆绿素对大鼠肝脏有细胞保护作用,对长期缺血再灌注损伤有保护作用。[10]它还显示出抗氧化活性。[11]

包裝

无底玻璃瓶。内含物在插入的融合锥体内。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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存取文件庫

Biological implications of heme metabolism.
Sassa, S.
Journal of Clinical Biochemistry and Nutrition, 38, 138-155 (2006)
Tracking multiple genomic elements using correlative CRISPR imaging and sequential DNA FISH
Guan J, et al.
Biophysical Journal, 112(6), 1077-1084 (2017)
Nader G Abraham et al.
Pharmacological reviews, 60(1), 79-127 (2008-03-08)
This review is intended to stimulate interest in the effect of increased expression of heme oxygenase-1 (HO-1) protein and increased levels of HO activity on normal and pathological states. The HO system includes the heme catabolic pathway, comprising HO and
Constantino Fondevila et al.
Hepatology (Baltimore, Md.), 40(6), 1333-1341 (2004-11-27)
Heme oxygenase (HO-1) provides a cellular defense mechanism during oxidative stress and catalyzes the rate-limiting step in heme metabolism that produces biliverdin (BV). The role of BV and its potential use in preventing ischemia/reperfusion injury (IRI) had never been studied.
Linear tetrapyrroles as functional pigments in chemistry and biology.
Mizutani, T. and Yagi, S.
Journal of Porphyrins and Phthalocyanines, 8, 226-237 (2004)

Questions

1–4 of 4 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. What is the refractive index and absorption index of Biliverdin Hydrochloride (30891)?

    1 answer
    1. There are no specific quality tests performed on this product to verify refractive or absorption properties. There are some details available in scientific literature for spectral properties with authors at the Chinese Academy of Science describing bilverdin as a NIR absorbing pigment. Please see the citation below for more details and refer specifically to figure 1B on page 2 of the publication.

      R. R. Xing, Q. L. Zou, C. Q. Yuan, L. Y. Zhao, R. Chang, X. H. Yan, Advanced Materials 2019, 31, 1900822. https://doi.org/10.1002/adma.201900822

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  4. Is Biliverdin hydrochloride #30891 suitable for preparing a Biliverdin solution?

    1 answer
    1. Product 30891 is a solid and can be reconstituted to make a solution. Biliverdin (hydrochloride) can be dissolved in organic solvents such as DMSO and dimethyl formamide (DMF) that should be purged with an inert gas, with a solubility of approximately 20 mg/ml. However, it is sparingly soluble in aqueous buffers.

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