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重要文件

Y0000462

托拉塞米

European Pharmacopoeia (EP) Reference Standard

同義詞:

Torsemide, Demadex, N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

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About This Item

經驗公式(希爾表示法):
C16H20N4O3S
CAS號碼:
分子量::
348.42
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
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等級

pharmaceutical primary standard

API 家族

torasemide

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

形式

neat

SMILES 字串

CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2

InChI

1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

InChI 密鑰

NGBFQHCMQULJNZ-UHFFFAOYSA-N

基因資訊

human ... SLC12A1(6557)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Torasemide for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

Torsemide is a loop diuretic and inhibitor of the Na+/K+/2Cl- carrier system.
Torsemide is a loop diuretic of the pyridine-sulfonylurea class with antialdosteronergic properties and inhibitor of the Na+/K+/2Cl- carrier system.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Sanjay Gupta et al.
European journal of heart failure, 12(7), 746-752 (2010-06-08)
Diuretics, when used to treat congestion in patients with chronic heart failure, improve symptoms and, perhaps, prognosis but little information is available to guide their use in patients with left ventricular systolic dysfunction (LVSD) who are not congested. Chronic diuretic
Mark A Oyama et al.
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology, 13(4), 287-292 (2011-10-28)
Diuretics are a mainstay of therapy in dogs with heart failure. In dogs with advanced heart failure, moderate to high doses of loop diuretics such as furosemide are used with diminishing effects as profound activation of neuroendocrine systems promote signs
J Strobel et al.
Deutsche medizinische Wochenschrift (1946), 136(22), 1207-1210 (2011-05-26)
A 27-year-old woman was admitted to the emergency room because of dyspnoea. Two months earlier she had given birth to a healthy young boy via cesarean section. Computed tomography showed acute embolism in both pulmonary arteries. Chest X-ray and echocardiography
Carmen Acuña
Drugs of today (Barcelona, Spain : 1998), 46 Suppl E, 1-15 (2010-10-12)
Chronic heart failure (CHF) is the cause of significant morbimortality all over the world and its incidence and prevalence are increasing. Fluid retention and volume overload are responsible of large part of morbility related to heart failure. There are a
[Frequent drug interactions in old age].
C C Wagner et al.
Praxis, 98(21), 1185-1190 (2009-10-22)

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