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Y0000109

硫柳汞钠

European Pharmacopoeia (EP) Reference Standard

同義詞:

Mercury-([o-carboxyphenyl]thio)ethyl 钠盐, 乙基噻吩酸 钠盐, 乙汞硫柳酸钠, 乙汞硫水杨酸 钠盐

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About This Item

線性公式:
2-(C2H5HgS)C6H4CO2Na
CAS號碼:
分子量::
404.81
Beilstein:
8169555
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

thimerosal

製造商/商標名

EDQM

mp

234-237 °C (dec.) (lit.)

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI 密鑰

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Thimerosal EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

硫柳汞是一种巯基(硫醇)氧化剂,能抑制多种巯基依赖性酶和蛋白质,如PI3激酶依赖性蛋氨酸合成酶、谷氨酸转运受体和Na++K+依赖性ATP酶。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

免責聲明

As part of the corporation global plan to support the Minamata Convention in eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. The sales of thimerosal will be restricted for approved applications only, such as preservative in vaccine manufacturing, preservative in eye cosmetics, research use within academia (excluding preservation intent) and as reference material only.

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act , European Biocidal Products Regulation, Canada′s Pest Management Regulatory Agency, Turkey′s Biocidal Products Regulation, Korea′s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

訊號詞

Danger

危險分類

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

標靶器官

Kidney

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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J G Elferink
General pharmacology, 33(1), 1-6 (1999-07-31)
An overview of the literature concerning the effects of thimerosal is presented. Because of its antibacterial effect, thimerosal is used for a variety of practical purposes such as antiseptic and preservative. In biomedical studies, thimerosal is used as a sulfhydryl
H Möller
Contact dermatitis, 31(4), 209-213 (1994-10-01)
By and large, positive patch tests with thimerosal lack clinical relevance and should cause concern neither to the dermatologist nor to the patient. The substance should be retained in standard test series for scientific purposes, but on clinical grounds its
L Magos
Journal of applied toxicology : JAT, 23(4), 263-269 (2003-07-29)
The decomposition rate of organomercurials and the potency of the blood-brain barrier increase with the size of the organic radical. Thus methylmercury damages the brain more than thimerosal does, and when intake limits set for methylmercury are applied to thimerosal
Sarah K Parker et al.
Pediatrics, 114(3), 793-804 (2004-09-03)
The issue of thimerosal-containing vaccines as a possible cause of autistic spectrum disorders (ASD) and neurodevelopmental disorders (NDDs) has been a controversial topic since 1999. Although most practitioners are familiar with the controversy, many are not familiar with the type
José G Dórea
Neurochemical research, 36(6), 927-938 (2011-02-26)
There is a need to interpret neurotoxic studies to help deal with uncertainties surrounding pregnant mothers, newborns and young children who must receive repeated doses of Thimerosal-containing vaccines (TCVs). This review integrates information derived from emerging experimental studies (in vitro

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