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PHR1289

Supelco

马来酸依那普利

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

依那普利 马来酸盐, ( S )-N-[1-(乙氧基羰基)-3-苯基丙基]-Ala-Pro 马来酸盐

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About This Item

經驗公式(希爾表示法):
C20H28N2O5 · C4H4O4
CAS號碼:
分子量::
492.52
EC號碼:
分類程式碼代碼:
41116107
NACRES:
NA.24
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等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP 741
traceable to Ph. Eur. E0109000
traceable to USP 1235300

API 家族

enalapril

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-30°C

SMILES 字串

C[C@@H](C(N1[C@H](C(O)=O)CCC1)=O)N[C@H](CC(OCC)=O)CCC2=CC=CC=C2.O=C(OO)/C=C\C(O)=O

InChI

1S/C21H30N2O5.C4H4O5/c1-3-28-19(24)14-17(12-11-16-8-5-4-6-9-16)22-15(2)20(25)23-13-7-10-18(23)21(26)27;5-3(6)1-2-4(7)9-8/h4-6,8-9,15,17-18,22H,3,7,10-14H2,1-2H3,(H,26,27);1-2,8H,(H,5,6)/b;2-1-/t15-,17-,18-;/m0./s1

InChI 密鑰

UQKQUZOIQFOJOI-KJHLASMFSA-N

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一般說明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Enalapril Maleate is a drug, which is widely used as an antihypertensive and a vasodilator in congestive heart failure. It is a derivative of 2 amino acids such as L-alanine and L-proline.[1]

應用

Enalapril Maleate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[2][1] using derivative UV spectrophotometry[2] and chromatography techniques.[2][1]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

一种长效血管紧张素转换酶抑制剂。

分析報告

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAC3898 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形圖

Health hazard

訊號詞

Warning

危險聲明

危險分類

Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2


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分析證明 (COA)

Lot/Batch Number

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Determination of hydrochlorothiazide and enalapril maleate in tablet formulations by reversed-phase HPLC
Al-Momani GI
Turkish Journal of Chemistry, 25(1), 49-54 (2001)
Simultaneous determination of enalapril maleate and hydrochlorothiazide in tablets by derivative UV spectrophotometry and high-performance liquid chromatography
Carlucci G, et al.
International Journal of Pharmaceutics, 93(1-3), 245-248 (1993)
Eran Leshem-Rubinow et al.
Mayo Clinic proceedings, 87(12), 1189-1195 (2012-11-13)
To investigate whether treatment initiated with an angiotensin-converting enzyme inhibitor (ACE-I) or an angiotensin II receptor blocker (ARB) for patients with ischemic heart disease, hypertension, or diabetes causes a reduction in hemoglobin (Hb) levels. This was a retrospective cohort analysis
Donald E Stull et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 16(1), 164-176 (2013-01-23)
To present a step-by-step example of the examination of heterogeneity within clinical trial data by using a growth mixture modeling (GMM) approach. Secondary data from a longitudinal double-blind clinical drug study were used. Patients received enalapril or placebo and were
Changhyun Lee et al.
Life sciences, 95(1), 29-39 (2013-11-19)
Enalapril, an angiotensin-converting enzyme (ACE) inhibitor, has pleiotropic effects such as anti-inflammatory effects. This study investigated the effect of enalapril on the nuclear factor-kappa B (NF-κB) pathway and on experimental colitis. The human intestinal epithelial cell (IEC) line COLO 205

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