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重要文件

PHR1282

Supelco

硫唑嘌呤

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

6-[(1-甲基-4-硝基-1H-咪唑-5-基)硫代]-1H-嘌呤

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About This Item

經驗公式(希爾表示法):
C9H7N7O2S
CAS號碼:
分子量::
277.26
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
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等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP 26
traceable to Ph. Eur. A1500000
traceable to USP 1046001

API 家族

azathioprine

CofA

current certificate can be downloaded

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-30°C

SMILES 字串

Cn1cnc(c1Sc2ncnc3[nH]cnc23)[N+]([O-])=O

InChI

1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

InChI 密鑰

LMEKQMALGUDUQG-UHFFFAOYSA-N

基因資訊

human ... PPAT(5471)

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一般說明

Azathioprine is a potentially useful antileukaemic drug,[1] with immunosuppressive action, which is administered orally or by I.V route. It is widely used to treat a variety of auto-immune disorders and also has a marked effect on T-lymphocytes and suppresses cell mediated immunity.[2]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

Azathioprine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[1][2] using 1H NMR spectroscopy[1] and spectrophotometric techniques.[2]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析報告

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA0017 in the slot below. This is an example certificate only and may not be the lot that you receive.

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3


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分析證明 (COA)

Lot/Batch Number

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Quantitative determination of azathioprine in tablets by 1H NMR spectroscopy
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Journal of Pharmaceutical and Biomedical Analysis, 21(3), 685-690 (2000)
Björn Pasternak et al.
American journal of epidemiology, 177(11), 1296-1305 (2013-03-22)
Increased risks of lymphoma and skin cancer associated with thiopurine use among patients with inflammatory bowel disease have been shown, but data on the overall cancer risk are limited. We conducted a historical cohort study of 45,986 patients with inflammatory
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